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Tag: Inflammation

Most patients with immunoglobulin G subclass 4-related disease have increased levels of immunoglobulin E

Increases in IgE, Eosinophils, Mast Cells Can ID IgG4-RD

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Levels of IgE at diagnosis may be able to identify patients with IgG4-related disease, disease relapse
Ultrasonography findings seem to correlate well with the disease activity of idiopathic inflammatory myopathies

Ultrasound Findings Correlate With Inflammatory Myopathies

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While there is not a single ultrasound pattern, findings tied to disease activity
Data obtained from a pilot study

ENRGISE Pilot Study Will Inform Larger Trial of IL-6 in Seniors

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Pilot study expected to provide data on recruitment yields, feasibility, meds tolerance, adherence
Tocilizumab (Actemra) combined with a 26-week prednisone taper is superior to either 26-week or 52-week prednisone tapering plus placebo with regard to sustained glucocorticoid-free remission in patients with giant-cell arteritis

Tocilizumab Effective for Treatment of Giant-Cell Arteritis

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Longer follow-up called for to determine the durability of remission and safety
Patients with obsessive-compulsive disorder have high levels of brain inflammation

High Levels of Brain Inflammation Seen in OCD

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Researchers find inflammation 32 percent higher in six brain regions that play a role in OCD
Anti-tumor necrosis factor-α therapy improves sleep quality in patients with  ankylosing spondylitis without any improvement in polysomnography measures

Anti-TNF-α Rx Improves Sleep Quality in Ankylosing Spondylitis

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Patients see reduction in PSQI scores, but no change in polysomnography parameters
The combination of extra virgin olive oil and ibuprofen at a therapeutic dose is superior to the two compounds used separately

Olive Oil, Ibuprofen May Have Synergistic Effects

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Synergistic analgesic, anti-pyretic, anti-inflammatory effects seen in animal model
Most patients with active uveitis of unknown origin with abnormal chest radiographs have findings consistent with sarcoidosis

Abnormal Chest Radiograph in Active Uveitis Often Sarcoidosis

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Fifteen percent of patients with active uveitis of unknown origin have abnormal chest radiographs
In a case report published online May 23 in the Annals of Internal Medicine

Severe Cutaneous Adverse Effect From Tocilizumab Described

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Diffuse, persistent, pruritic maculopapular rash developed 10 days after tocilizumab treatment
Mepolizumab is associated with significantly more weeks in remission than placebo among patients with eosinophilic granulomatosis with polyangiitis

Remission Up for Mepolizumab in Eosinophilic Granulomatosis

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Significantly more weeks of accrued remission for mepolizumab treatment versus placebo