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Tag: Immunotherapy

For children and young adults receiving CD19 chimeric antigen receptor T-cell infusion

Infection Risk Up in Month After CAR T-Cell Immunotherapy

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Infection rates increase in patients with ALL aged ≤26 years in first month, then decrease at days 29 to 90
Adding tucatinib to trastuzumab and capecitabine is associated with improved progression-free and overall survival among heavily pretreated patients with human epidermal growth factor receptor 2-positive metastatic breast cancer

SABCS: Addition of Tucatinib Ups Survival in HER2+ Metastatic Breast Cancer

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In heavily pretreated patients, adding tucatinib versus placebo improves overall, progression-free survival
The June 2018 U.S. Food and Drug Administration label restriction on first-line immunotherapy for advanced bladder cancer was associated with a decrease in immunotherapy use and an increase in chemotherapy use

FDA Labeling Restriction Quickly Reflected in Oncology Practice

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FDA label change linked to decrease in immunotherapy use, increases in chemotherapy use, PD-L1 testing
In moderate-to-severe ulcerative colitis

Vedolizumab Beats Adalimumab for Ulcerative Colitis Remissions

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But not for corticosteroid-free clinical remission; also, ustekinumab superior to placebo
For patients with non-small cell lung cancer

Electronic Nose Analysis May Predict Response to Anti-PD-1 Therapy in NSCLC

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Initial breath analysis predicts individual treatment response to anti-PD-1 therapy at three months
Allergy immunotherapy is associated with a decreased risk for asthma progression

Allergy Immunotherapy May Decrease Asthma Progression

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Findings strongest for youngest patients with incident asthma treated in routine care
A little used immunosuppression regimen may substantially improve survival following lung transplant

Underused Drug Combo May Up Survival in Lung Transplant

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No antibody induction therapy with sirolimus plus tacrolimus associated with maximal survival
For patients with multiple myeloma receiving immunomodulatory drugs

SAVED Score Can Predict Risk for VTE in Multiple Myeloma

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Score outperforms current NCCN guidelines for MM patients receiving immunomodulatory therapy
Polivy (polatuzumab vedotin-piiq)

Chemoimmunotherapy Regimen Approved to Treat DLBCL

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Polivy approved in combination with bendamustine, rituximab for diffuse large B-cell lymphoma
Current peanut oral immunotherapy approaches are associated with increased risk and frequency of allergic reactions

Peanut Oral Immunotherapy May Up Allergic Reaction Risk

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Increase seen in anaphylaxis risk, anaphylaxis frequency, epinephrine use with oral immunotherapy