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Tag: Hormone Replacement Therapy

Long-term use of systemic hormone therapy may be associated with an increased risk for Alzheimer disease

Long-Term Systemic Hormone Therapy May Up Alzheimer Risk

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Risk increases associated with hormone therapy exposure over 10 years in women <60 years at initiation
People receiving hormone therapy during gender transition have an increased risk for cardiovascular events

Cardiovascular Risk Increased During Gender Transition

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Transwomen had higher incidence of strokes, VTEs than reference men and women
For postmenopausal women

Prevalence of Knee OA Lower With Menopausal Hormone Therapy

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Odds ratio for knee osteoarthritis was 0.7 in MHT group versus non-MHT group in multivariable model
The Women's Health Initiative recommendations for menopausal hormone therapy use issued in 2002 have been widely adopted

Menopausal Hormone Tx Use Down Post-WHI Recommendations

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But large declines seen in subgroups for whom MHT is recommended, including younger women
Oral hormone replacement therapy is associated with an increased risk for venous thromboembolism

Transdermal HRT Not Linked to Increased Risk for VTE

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But oral estrogen-only and combined hormone replacement tx tied to venous thromboembolism risk
Women who receive menopausal hormone therapy have reduced age-adjusted visceral adipose tissue

Menopausal Hormone Therapy Linked to Reduced Abdominal Fat

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No residual effect for past users, including early discontinuers of menopause hormone treatment
Taking menopausal hormone therapy may have long-term effects on the brain

Hormone Therapy May Impact Brain Structure, Cognition

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But 3 years after menopausal HT, change in brain volumes not significantly different from placebo
Menopausal hormone therapy use is associated with less pronounced kyphosis compared with never-use

Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis

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Continuous and remote past HT users had less kyphosis in minimally-, fully-adjusted models
The U.S. Preventive Services Task Force recommends against use of hormone therapy for preventing chronic conditions in postmenopausal women. These findings form the basis of a final recommendation statement published in the Dec. 12 issue of the Journal of the American Medical Association.

USPSTF Recommends Against Hormone Tx Post Menopause

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Benefits do not outweigh harms of using hormone therapy for prevention of chronic conditions
Menopausal hormone therapy is not tied to any increase in long-term all-cause or cause-specific mortality

Hormone Therapy in Menopause Not Tied to Increased Mortality

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Findings based on long-term follow up of both all-cause, cause-specific deaths