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Tag: Hormone Replacement Therapy

Longer use of hormone therapy is associated with high muscle mass and a low prevalence of sarcopenia in postmenopausal women

Longer Hormone Therapy Tied to Less Muscle Loss in Menopause

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In large study of postmenopausal women, sarcopenia lower in participants with history of prolonged HT
For postmenopausal women

SABCS: Breast Cancer Rates Opposite for Estrogen, Estrogen + Progestin

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In postmenopausal women, breast cancer incidence down with estrogen alone, up with CEE + MPA
For women aged 50 to 79 years

Age Modifies Effects of Estrogen Therapy in Women Without Ovaries

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Women aged 50 to 59 years with BSO had treatment-associated decrease in all-cause mortality
Use of menopausal hormone therapy is associated with an increased incidence of breast cancer

Type and Timing of Menopausal HRT Affect Risk for Breast Cancer

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Some excess risk persists for >10 years after ceasing therapy; magnitude varies with duration of use
Hormone therapy does not significantly impact muscle mass in postmenopausal women

Hormone Tx Not Tied to Change in Muscle Mass in Older Women

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No significant beneficial or detrimental association seen in postmenopausal women
Women with premature ovarian insufficiency receiving hormone therapy have poor sleep quality

Premature Ovarian Insufficiency Tied to Poor Sleep Quality

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Patients take longer to fall asleep, use more sleep aids, have more fatigue
Long-term use of systemic hormone therapy may be associated with an increased risk for Alzheimer disease

Long-Term Systemic Hormone Therapy May Up Alzheimer Risk

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Risk increases associated with hormone therapy exposure over 10 years in women <60 years at initiation
People receiving hormone therapy during gender transition have an increased risk for cardiovascular events

Cardiovascular Risk Increased During Gender Transition

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Transwomen had higher incidence of strokes, VTEs than reference men and women
For postmenopausal women

Prevalence of Knee OA Lower With Menopausal Hormone Therapy

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Odds ratio for knee osteoarthritis was 0.7 in MHT group versus non-MHT group in multivariable model
The Women's Health Initiative recommendations for menopausal hormone therapy use issued in 2002 have been widely adopted

Menopausal Hormone Tx Use Down Post-WHI Recommendations

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But large declines seen in subgroups for whom MHT is recommended, including younger women