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ACAAI: Gene-Editing Therapy Reduces Angioedema Attacks in Hereditary Angioedema

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Reduction of 75 and 77 percent seen in estimated mean monthly attack rate with 25-mg, 50-mg NTLA-2002 versus placebo

Acupuncture Offers Some Benefit in Chronic Spontaneous Urticaria

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However, differences between acupuncture and sham acupuncture, wait-list control did not meet threshold for minimal clinically important difference

Ligelizumab appears to be a safe and effective treatment option for chronic spontaneous urticaria

Ligelizumab Safely, Effectively Treats Hives

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Doses of 72 mg or 240 mg tied to complete control of symptoms after 12-week trial
Omalizumab

Omalizumab Effective for Chronic Spontaneous Urticaria

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In small study, 85 percent of refractory CSU patients had complete response; rest had well-controlled dx
HIV-infected and HIV-exposed but uninfected children have lower cognitive and motor scores than HIV-unexposed and uninfected children

Review: Lower Cognitive Scores for HIV+, HIV-Exposed Children

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Lower scores for HIV+, HIV-exposed uninfected children versus HIV-unexposed and uninfected
C-reactive protein levels are frequently elevated in patients with chronic spontaneous urticaria

CRP Levels Potentially Useful in Chronic Spontaneous Urticaria

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Elevated levels appear clinically relevant in patients with condition
Chronic spontaneous urticaria interferes with sleep and daily activity

Considerable Humanistic Impact for Chronic Spontaneous Urticaria

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Two-thirds of patients with CSU report angioedema, which significantly affects health-related QoL
The autologous serum skin test can be combined with additional parameters to best identify chronic autoimmune urticaria

ASST Combined With Other Tests Best IDs Autoimmune Urticaria

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ASST combined with all specific parameters has sensitivity of 97 percent, specificity of 86 percent
Recommendations for the use of antiretroviral therapy in HIV infection have been updated for adults

Recommendations Updated for Use of Antiretroviral Tx in HIV

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Preexposure prophylaxis for at-risk individuals; postexposure prophylaxis for after exposure
Just over one-third of chronic cold urticaria patients benefit from treatment with doxycycline

Doxycycline Helps One-Third of Chronic Cold Urticaria Patients

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Critical temperature thresholds do not predict which patients benefit from treatment