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FDA Approves Dupixent for Chronic Spontaneous Urticaria

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Approval granted for adults and children 12 years and older who remain symptomatic despite antihistamine treatment

Remibrutinib Beneficial for Urticaria After H1-Antihistamine Treatment

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Remibrutinib results in significant improvement in composite measure of itching and hives at week 12 after second-generation H1-antihistamine treatment

ACAAI: Gene-Editing Therapy Reduces Angioedema Attacks in Hereditary Angioedema

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Reduction of 75 and 77 percent seen in estimated mean monthly attack rate with 25-mg, 50-mg NTLA-2002 versus placebo

Acupuncture Offers Some Benefit in Chronic Spontaneous Urticaria

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However, differences between acupuncture and sham acupuncture, wait-list control did not meet threshold for minimal clinically important difference

Ligelizumab appears to be a safe and effective treatment option for chronic spontaneous urticaria

Ligelizumab Safely, Effectively Treats Hives

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Doses of 72 mg or 240 mg tied to complete control of symptoms after 12-week trial
Omalizumab

Omalizumab Effective for Chronic Spontaneous Urticaria

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In small study, 85 percent of refractory CSU patients had complete response; rest had well-controlled dx
HIV-infected and HIV-exposed but uninfected children have lower cognitive and motor scores than HIV-unexposed and uninfected children

Review: Lower Cognitive Scores for HIV+, HIV-Exposed Children

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Lower scores for HIV+, HIV-exposed uninfected children versus HIV-unexposed and uninfected
C-reactive protein levels are frequently elevated in patients with chronic spontaneous urticaria

CRP Levels Potentially Useful in Chronic Spontaneous Urticaria

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Elevated levels appear clinically relevant in patients with condition
Chronic spontaneous urticaria interferes with sleep and daily activity

Considerable Humanistic Impact for Chronic Spontaneous Urticaria

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Two-thirds of patients with CSU report angioedema, which significantly affects health-related QoL
The autologous serum skin test can be combined with additional parameters to best identify chronic autoimmune urticaria

ASST Combined With Other Tests Best IDs Autoimmune Urticaria

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ASST combined with all specific parameters has sensitivity of 97 percent, specificity of 86 percent