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Adverse reactions to St. John's wort are similar to those reported for fluoxetine

Similar Adverse Effects Seen for St. John’s Wort, Fluoxetine

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Majority reported concern females, 26 to 50 years of age
Topical baicalein

ARVO: Topical Flavonoid Cuts Intraocular Pressure in Rodents

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Topical administration lowers IOP; effect mediated in part by facilitation of outflow
Limited evidence supports use of herbal remedies in gastrointestinal disorders

Limited Evidence Supporting Herbal Meds in GI Disorders

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Lack of evidence for adherence to good manufacturing practice guidelines