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Tag: Heartburn / GERD / Indigestion

Mortality and reoperation rates are very low among working-age patients with severe gastroesophageal reflux disease undergoing primary laparoscopic fundoplication

Mortality Low for Laparoscopic Surgery in Severe GERD

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For patients with severe GERD, low rates of 90- and 30-day mortality and 90-day reoperation
For patients requiring dual antiplatelet therapy

ACC: PPI Tx Also Beneficial for Those on Low-Dose Aspirin

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Gastroprotection with PPI therapy reduced primary GI end point in patients on low-dose aspirin
Use of proton pump inhibitors may be linked to long-term kidney damage

Proton Pump Inhibitors Linked to Chronic Kidney Disease

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While study can't prove cause-and-effect, increasing damage seen as dose rises
CYP2C19 polymorphism impacts response to proton pump inhibitor treatment in gastroesophageal reflux disease

CYP2C19 Polymorphism Impacts Response to PPI Tx in GERD

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Meta-analysis shows lower efficacy rates to proton pump inhibitors for rapid metabolizer genotype
Proton pump inhibitors appear to be linked with increased risk of chronic kidney disease

ASN: PPIs Linked to Higher Risk of Chronic Kidney Disease

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But studies weren't designed to prove proton pump inhibitors are responsible for the increase
Chronic proton pump inhibitor exposure is associated with mild hyperparathyroidism in elderly adults

Chronic PPI Exposure Tied to Hyperparathyroidism in Elderly

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Correlation persists regardless of concurrent oral bisphosphonate administration
For U.S. adults with gastroesophageal reflux disease

Proton Pump Inhibitors Linked to Increased Risk of MI

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No increased risk seen with H2-blockers
Anxiety and depression are linked to increased severity of retrosternal pain and heartburn and reduced quality of life among patients with gastroesophageal reflux disease

Anxiety, Depression Impact Symptoms, QoL in GERD

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Increased anxiety, depression linked to increased severity of retrosternal pain and heartburn
For patients with gastroesophageal reflux disease

Review: Radioablation Offers No Benefit for GERD Patients

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No improvement in terms of mean time spent with pH less than 4, ability to stop PPIs, HRQoL
Nocturnal gastroesophageal reflux disease appears to be a risk factor for non-infectious rhinitis

Nocturnal GERD Tied to Non-Infectious Rhinitis

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Greater number of reflux episodes reported tied to higher risk of non-infectious rhinitis