Tag: Heartburn / GERD / Indigestion
Laparoscopic Antireflux Sx May Provide Added Benefits in GERD
Lasting reduction in esophageal acid reflux with LARS and esomeprazole; greater reduction with LARS
Lasting Safety, Efficacy for Magnetic Device in GERD
Lasting improvements in health-related QoL with magnetic sphincter augmentation device
Proton Pump Inhibitors Tied to Chronic Kidney Disease
Risk increased the longer people used the medications
Mortality Low for Laparoscopic Surgery in Severe GERD
For patients with severe GERD, low rates of 90- and 30-day mortality and 90-day reoperation
ACC: PPI Tx Also Beneficial for Those on Low-Dose Aspirin
Gastroprotection with PPI therapy reduced primary GI end point in patients on low-dose aspirin
Proton Pump Inhibitors Linked to Chronic Kidney Disease
While study can't prove cause-and-effect, increasing damage seen as dose rises
CYP2C19 Polymorphism Impacts Response to PPI Tx in GERD
Meta-analysis shows lower efficacy rates to proton pump inhibitors for rapid metabolizer genotype
ASN: PPIs Linked to Higher Risk of Chronic Kidney Disease
But studies weren't designed to prove proton pump inhibitors are responsible for the increase
Chronic PPI Exposure Tied to Hyperparathyroidism in Elderly
Correlation persists regardless of concurrent oral bisphosphonate administration
Proton Pump Inhibitors Linked to Increased Risk of MI
No increased risk seen with H2-blockers
