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Home Tags Heart / Stroke-Related: High Cholesterol

Tag: Heart / Stroke-Related: High Cholesterol

Between 1999 and 2016

Favorable Trends Seen in Lipids, Apolipoprotein B in U.S. Youth

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Adjusted mean total cholesterol level decreased from 1999-2000 to 2015-2016 in youth aged 6 to 19 years
More than one-third of patients on statin therapy fail to achieve therapeutic low-density lipoprotein cholesterol thresholds

One-Third of Patients on Statins Do Not Reach Target Thresholds

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Not reaching thresholds places patients at increased risk for cardiovascular events
Statin use may lower the risk for primary open-angle glaucoma

Longer Duration of Statin Use Linked to Lower Risk for Glaucoma

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Self-reported high cholesterol levels without statin use tied to higher glaucoma risk
A machine learning classifier can effectively identify patients at risk for familial hypercholesterolemia

Machine Learning IDs Risk for Familial Hypercholesterolemia

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Classifier developed using EHR data identifies patients at highest probability threshold for FH
Bempedoic acid

Adding Bempedoic Acid to Statin Therapy Reduces LDL Cholesterol

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Genetic variants mimicking effect of ATP citrate lyase inhibitors, statins lower LDL-C in same way
There is seasonal variation in achievement of the guideline targets for hemoglobin A1c

Achievement of Targets in T2DM Varies by Season

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Achievement rates for all three targets and for HbA1c, BP, LDL-C are lowest in the winter
Candesartan plus hydrochlorothiazide

Lowering BP, Lipids in Healthy Elderly Has No Cognitive Effect

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Candesartan/hydrochlorothiazide, rosuvastatin, combination therapy do not affect cognitive decline
Higher triglycerides is associated with a decreased risk of cognitive decline

Higher Triglycerides May Be Protective in the Very Elderly

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Higher triglyceride levels tied to lower risk of cognitive decline, ADL decline, frailty aggravation, and death
For patients with a recent acute coronary syndrome receiving a statin

Price of Alirocumab Would Have to Be Cut to Be Cost-Effective

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Price of alirocumab would have to decrease from original cost of $14,560 to $1,974 to be cost-effective
Adherent patients receiving high-intensity statin and/or ezetimibe therapy have the lowest cardiovascular risk

Adherence and Intensity of Lipid-Lowering Tx Influence CV Risk

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Lowest risk seen for adherent patients receiving high-intensity statin and/or ezetimibe regimen