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Tag: Heart / Stroke-Related: High Cholesterol

Initiation of statin therapy during childhood in patients with familial hypercholesterolemia slows the progression of carotid intima-media thickness and reduces the risk for cardiovascular disease over 20 years

Statins in Childhood Aid Familial Hypercholesteremia Outcomes

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Patients show slowed progression of carotid intima-media thickness, lower risk for cardiovascular disease
Even with care in specialty clinics

More Aggressive Tx Needed for Familial Hypercholesterolemia

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Even with care in specialty clinics, LDL cholesterol levels remain above targets for most patients
Patients with rejected or abandoned prescriptions for proprotein convertase subtilisin kexin type 9 inhibitors have a significantly increased risk for cardiovascular events than those with paid prescriptions

CV Event Risk Up With Rejected, Abandoned PCSK9i Prescriptions

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Rejection rates higher for PCSK9i prescriptions for women, racial minorities, lower-income groups
Among those receiving alirocumab in addition to statin therapy to reduce the risk for another cardiovascular event after a recent acute coronary syndrome

Alirocumab Cuts CV Absolute Risk the Most for Those With Diabetes

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Findings seen in prespecified analysis; alirocumab did not increase risk for new diabetes
The majority of young heart attack patients with familial hypercholesterolemia still have elevated cholesterol levels a year later

More Aggressive Statin Tx Needed After Heart Attack in Young Patients

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Majority of patients with heart attack <50 years still have high cholesterol one year later
Lowering serum cholesterol levels in patients with type 2 diabetes is associated with diabetic polyneuropathy

Lowering Cholesterol Levels May Worsen Nerve Damage in T2DM

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Higher number of nerve lesions, declining nerve conduction velocities and amplitudes seen
Low-density lipoprotein cholesterol is associated with the probability of developing early-onset Alzheimer disease

Higher LDL-C Levels Linked to Early-Onset Alzheimer Disease

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Cases with EOAD have higher levels of LDL-C, greater frequency of rare genetic coding variants of APOB
Fasting before a cholesterol test is not necessary when evaluating risk for cardiovascular events

Nonfasting Lipid Levels Adequate for Assessing Cardiovascular Risk

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Fasting, nonfasting levels show similar associations with cardiovascular events even for patients on statins
Removal of low-density lipoproteins (LDL) by extracorporeal filtration during LDL-apheresis is associated with a large reduction in mean LDL in acute coronary syndrome patients treated with percutaneous coronary intervention

LDL Decreased With LDL-Apheresis in ACS Patients

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Significant reduction seen in mean LDL among patients with acute coronary syndrome treated with PCI
Data from a blood donor screening program could represent a novel strategy for identifying familial hypercholesterolemia

Blood Donor Screening Data IDs Familial Hypercholesterolemia

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Highest estimated prevalence of FH seen in young versus older donors, and in men versus women