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Tag: Heart / Stroke-Related: High Cholesterol

The FIND FH model can successfully identify individuals with familial hypercholesterolemia from a scan of large

AI Model Helps ID Those at Risk for Familial Hypercholesterolemia

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Model may identify more who are at risk while substantially reducing the number of people screened
Initiation of statin therapy during childhood in patients with familial hypercholesterolemia slows the progression of carotid intima-media thickness and reduces the risk for cardiovascular disease over 20 years

Statins in Childhood Aid Familial Hypercholesteremia Outcomes

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Patients show slowed progression of carotid intima-media thickness, lower risk for cardiovascular disease
Even with care in specialty clinics

More Aggressive Tx Needed for Familial Hypercholesterolemia

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Even with care in specialty clinics, LDL cholesterol levels remain above targets for most patients
Patients with rejected or abandoned prescriptions for proprotein convertase subtilisin kexin type 9 inhibitors have a significantly increased risk for cardiovascular events than those with paid prescriptions

CV Event Risk Up With Rejected, Abandoned PCSK9i Prescriptions

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Rejection rates higher for PCSK9i prescriptions for women, racial minorities, lower-income groups
Among those receiving alirocumab in addition to statin therapy to reduce the risk for another cardiovascular event after a recent acute coronary syndrome

Alirocumab Cuts CV Absolute Risk the Most for Those With Diabetes

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Findings seen in prespecified analysis; alirocumab did not increase risk for new diabetes
The majority of young heart attack patients with familial hypercholesterolemia still have elevated cholesterol levels a year later

More Aggressive Statin Tx Needed After Heart Attack in Young Patients

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Majority of patients with heart attack <50 years still have high cholesterol one year later
Lowering serum cholesterol levels in patients with type 2 diabetes is associated with diabetic polyneuropathy

Lowering Cholesterol Levels May Worsen Nerve Damage in T2DM

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Higher number of nerve lesions, declining nerve conduction velocities and amplitudes seen
Low-density lipoprotein cholesterol is associated with the probability of developing early-onset Alzheimer disease

Higher LDL-C Levels Linked to Early-Onset Alzheimer Disease

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Cases with EOAD have higher levels of LDL-C, greater frequency of rare genetic coding variants of APOB
Fasting before a cholesterol test is not necessary when evaluating risk for cardiovascular events

Nonfasting Lipid Levels Adequate for Assessing Cardiovascular Risk

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Fasting, nonfasting levels show similar associations with cardiovascular events even for patients on statins
Removal of low-density lipoproteins (LDL) by extracorporeal filtration during LDL-apheresis is associated with a large reduction in mean LDL in acute coronary syndrome patients treated with percutaneous coronary intervention

LDL Decreased With LDL-Apheresis in ACS Patients

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Significant reduction seen in mean LDL among patients with acute coronary syndrome treated with PCI