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Home Tags Heart / Stroke-Related: High Cholesterol

Tag: Heart / Stroke-Related: High Cholesterol

Migraine frequency and intensity seem to be positively associated with total cholesterol and low-density lipoprotein cholesterol

Migraine Frequency, Intensity Linked to Cholesterol Levels

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Number and intensity of crises reduced in association with reduction in total, LDL cholesterol
Intestinal microbiomes might help determine not only body fat levels

Gut Microbiome May Play Role in BMI, HDL Cholesterol Levels

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But more research needed to understand how different bacteria affect risk factors for heart disease
Two newly approved medications to treat high cholesterol are extremely overpriced compared to the health benefits they give to patients

ICER: New Cholesterol Drugs Highly Overpriced

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Newly FDA-approved Repatha and Praluent currently cost more than $14,000 per year
Repatha (evolocumab) has been approved by the U.S. Food and Drug Administration

FDA Approves Repatha for Certain Patients With High Cholesterol

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Approved for patients unable to get LDL cholesterol under control with current treatment options
The diabetes drug metformin changes metabolic profiles of three metabolites that may lower LDL cholesterol

Metabolic Changes With Metformin May Lower LDL-C

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Possible metabolic mechanism includes activation of AMPK, FADS suppression
At lower values of measured low-density lipoprotein cholesterol (LDL-C)

Calculated LDL-C Varies at Lower Values of Measured LDL-C

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For calculated LDL-C of 30 mg/dL, 95 percent confidence interval was 24 to 60 mg/dL
Praluent (alirocumab) injection has been approved by the U.S. Food and Drug Administration for use in addition to diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease

FDA Approves Praluent for Certain Cases of High Cholesterol

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First in a new class of injectable cholesterol-lowering medications
Updated guidelines for cholesterol management were released in 2013 by the American College of Cardiology and the American Heart Association. Now

New Guidelines Deemed Better for Identifying Statin Candidates

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New guidelines would have 13 million more Americans taking the cholesterol drugs, experts say
A joint clinical practice guideline for the management of dyslipidemia for cardiovascular disease risk reduction in adults has been summarized and published online June 22 in the Annals of Internal Medicine.

VA/DoD Release Guidelines for Dyslipidemia Management

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Key features include elimination of treatment targets, additional testing only when rationale clear
On Wednesday

FDA Panel Recommends Approval of Second PCSK9 Inhibitor

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Evolocumab (Repatha) for use in patients at very high risk for high cholesterol