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Tag: Heart / Stroke-Related: High Cholesterol

The U.S. Preventive Services Task Force has concluded that the evidence is currently insufficient to weigh the balance of benefits and harms of screening for lipid disorders in children and adolescents (aged 20 years or younger). These findings form the basis of a final recommendation statement published in the Aug. 9 issue of the Journal of the American Medical Association.

USPSTF: Evidence Lacking for Lipid Screening in Children, Teens

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I statement shows current evidence is insufficient to weigh balance of benefits and harms of screening
Most Medicare fee-for-service beneficiaries with dyslipidemia who initiate statins undergo baseline alanine aminotransferase and aspartate aminotransferase testing

Baseline ALT, AST Frequently Assessed With Statin Initiation

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Baseline testing rates 89.3, 88.8 percent for alanine aminotransferase, aspartate aminotransferase
Patients with heterozygous familial hypercholesterolemia have a significantly increased risk for coronary heart disease and atherosclerotic cardiovascular disease

CVD Risks Way Up in Familial Hypercholesterolemia

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Clinician-patient discussions on guideline-supported therapies can be informed by data
Very low target low-density lipoprotein cholesterol levels may not benefit all patients with preexisting heart disease

Moderately Low LDL May Be Enough to Ward Off CVD Risk

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Researchers find reduction to 70 mg/dL range not associated with additional benefit
For patients with type 2 diabetes with low-density lipoprotein cholesterol levels <2.0 mmol/L

Higher HDL-C Linked to Cardiac Risk With LDL-C <2.0 mmol/L

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Increased risk for cardiovascular events and all-cause mortality for patients with type 2 diabetes
ASGR1 mutation carriers have reduced levels of non-high-density lipoprotein cholesterol and reduced risk of coronary artery disease

ASGR1 Mutation Linked to Reduced Levels of Non-HDL-C

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Heterozygous mutation carriers have lower levels of non-HDL-C, reduced risk of coronary artery disease
The impact of high-density lipoprotein cholesterol on cardiovascular disease risk is modulated by triglycerides and low-density lipoprotein cholesterol

HDL-C Prediction of Heart Disease Modulated by TG, LDL-C

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Cardiovascular disease risk higher when low HDL-C accompanied by high triglycerides, LDL-C
Expert consensus guidance has been issued regarding the use of non-statin therapies to lower cholesterol in high-risk patients. The consensus document was published online April 1 in the Journal of the American College of Cardiology to coincide with presentation at the annual meeting of the American College of Cardiology

ACC: Expert Guidance Issued for Use of Non-Statin Therapies

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Authors recommend addition of ezetimibe at 10 mg/day for higher-risk patients
Familial hypercholesterolemia mutations are seen in less than 2 percent of individuals with low-density lipoprotein cholesterol ≥190 mg/dL

ACC: Prevalence of Familial Hypercholesterolemia <2 Percent

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For any given observed LDL cholesterol level, increased risk for CAD for FH mutation carriers
The "Paleo diet" may help older women lose weight

ENDO: ‘Paleo’ Diet May Benefit Heart Health Post Menopause

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Trendy eating plan may cut cholesterol, disease risks in postmenopausal women