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Tag: Heart / Stroke-Related: High Cholesterol

Fewer than half of patients prescribed PCSK9 inhibitors receive approval

About Half of Patients Receive Approval for PCSK9i Prescription

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Prescription abandonment linked to copay costs, with rates more than 75 percent for copays > $350
In patients with type 2 diabetes being treated with a dipeptidyl peptidase-4 inhibitor

Anagliptin Effect on LDL in T2DM Via ApoB-100 Synthesis

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Improvement appears mediated, at least in part, through suppression of apoB-100 synthesis
Use of anacetrapib is associated with lower incidence of major coronary events for patients with atherosclerotic vascular disease receiving intensive statins

Anacetrapib Linked to Lower Incidence of Coronary Events

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Lower incidence versus placebo for patients with atherosclerotic vascular dz receiving intensive statins
At its current price

More Evidence Evolocumab Exceeds Cost-Effectiveness

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Findings for addition of evolocumab to standard tx in atherosclerotic cardiovascular disease
The costs of PCSK9 inhibitors would have to be 71 percent lower to be deemed cost-effective

Cost-Effectiveness of PCSK9 Inhibitors Called Into Question

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Researchers say price would have to be between $4,000 and $5,000 per year to be cost-effective
There is no significant difference in cognitive function for patients treated with evolocumab or placebo added to statin therapy

Evolocumab Doesn’t Affect Cognition When Added to Statins

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No significant between-group difference for patients receiving evolocumab or placebo added to statins
Polygenic risk can mimic major monogenic mutation in severe hypertriglyceridemia

Case Highlights Polygenic Risk in Severe Hypertriglyceridemia

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Patient with hypertriglyceridemia had polymorphisms producing triglyceride risk score of 19
Replacing saturated fats with polyunsaturated fats and monounsaturated fats can reduce cardiovascular disease risk as much as statins

Replacing Saturated Fats With Healthy Fats Lowers CVD Risk

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Healthy fats can help reduce risk of cardiovascular disease as effectively as statins, researchers say
Two separate research groups say they've successfully reduced cholesterol in humans by using different methods to block the angiopoietin-like 3 (ANGPTL3) gene. The findings were published online May 24 in the New England Journal of Medicine.

Targeting ANGPTL3 Can Significantly Lower Cholesterol

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Two trials show promise for non-statin approach to cardiovascular disease prevention
The prevalence of elevated cardiovascular risk is low in normotensive

Findings Support More Targeted Approach to Cholesterol Screens

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Among normotensive nonsmokers without diabetes, very few at heightened risk of ASCVD