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Tag: Genetics

A gene variation associated with smoking longer and getting lung cancer at a younger age has been identified by researchers. The study was published in the May issue of the Journal of the National Cancer Institute.

Gene Variation May Impact Smoking Cessation Efforts

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Researcher suggests a change in screening policies
Genes may play a role in cardiac arrest risk among kidney patients who are on dialysis

Higher Risk of Cardiac Arrest in Dialysis May Be Genetic

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But more detailed genetic studies needed in the dialysis population
If genetic tests are only done on cancer tissue

Call for Gene Tests in Cancer to Include Normal Tissue

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Current practice of only focusing on tumor samples might adversely affect care
Children with poor metabolizer phenotype based on CYP2C19 have worse asthma control after six months of lansoprazole treatment

Lansoprazole Worsens Asthma Control in Poor Metabolizers

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After six months of treatment, worse control in children with poor CYP2C19 metabolizer phenotype
The strength of the placebo effect may depend on particular DNA

Placebo Response May Depend on Individual DNA

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But more questions than answers exist at this point
Short people may be more likely to have coronary artery disease

Higher Risk of Heart Disease Seen With Shorter Stature

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Increased risk possibly linked to the genetics that also determine height
The risk of breast and ovarian cancer varies with the type and location of BRCA1/2 mutations

Breast, Ovarian CA Risk Varies With BRCA Mutation Location

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Nonsense-mediated decay mutations linked to differential breast or ovarian cancer risk
Although many women with breast cancer are concerned about their genetic risk for other cancers -- as well as their relatives' risk for breast cancer -- almost half of these patients don't get information about genetic testing

Breast CA Patients Want, but May Not Get, Genetic Risk Discussion

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Almost half don't have conversation with doctor about potential for future problems
Skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 regulates insulin resistance in a sex-specific manner

PTEN Regulation of Insulin Resistance Is Sex Specific

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Women have downregulation of PTEN gene expression, upregulation of PTEN protein phosphorylation
Two single nucleotide polymorphisms have been identified which confer differential benefit for aspirin and/or nonsteroidal anti-inflammatory drug use in relation to colorectal cancer risk

Genetic Variation Impacts Aspirin/NSAID Link to CRC Risk

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Use of aspirin, NSAIDs lowers risk of CRC in association with genetic variation at two SNPs