Tag: Genetics
Age at NSCLC Diagnosis Tied to Odds of Targetable Phenotype
Younger age at diagnosis linked to increased frequency of targetable phenotype
c-Jun N-terminal Kinase Essential for HSV Reactivation
JNK signaling results in histone methyl-phospho switch on HSV lytic promoters
‘Suicide Gene Therapy’ Plus Radiation Effective in Prostate CA
Immunomodulatory in situ gene tx/IMRT with or without hormonal tx deemed feasible, safe
CYP2C19 Polymorphisms Impacts Citalopram Metabolism
CYP2C19*2 polymorphism seems to contribute to interindividual variability in CIT metabolism
MITF p.E318K Prevalence Similar, Regardless of CDKN2A
Mutation correlates with increased risk, especially for multiple primary melanoma, high nevi count
Cell-Free Circulating mtDNA Identifies Parkinson’s Disease
Reduced CSF ccf-mtDNA in patients with Parkinson's versus age-matched asymptomatic controls
Etiology of Leukemia in Breast Cancer Survivors Explored
Family history of cancer, inherited gene mutation seem to raise chances of secondary malignancy
CYP2C19 Polymorphism Impacts Response to PPI Tx in GERD
Meta-analysis shows lower efficacy rates to proton pump inhibitors for rapid metabolizer genotype
Plasmid-Mediated Polymyxin Resistance Identified
Emergence of plasmid-mediated polymyxin resistance mechanism ID'd in Enterobacteriaceae
Genetic Risk Score Can Differentiate Type 1, 2 Diabetes
GRS, with most discriminative ability coming from nine SNPs, can accurately ID T1D in young adults
