Tag: Genetics
Researchers Calculate Family Risk Estimates for Cancer
Estimated 33 percent of overall risk is genetic; certain types of cancer have additional risk
Support for First-Line Erlotinib in NSCLC With EGFR Mutations
And erlotinib therapy beyond progression may delay salvage tx for some patients
Early First Cancer in BRCA1/2 Ups Risk in Opposite Breast
For mutation carriers, age at diagnosis of first cancer predicts contralateral breast cancer risk
Meta-Analysis Confirms miR-21 Expression, Laryngeal CA Link
High miR-21 expression seen in laryngeal cancer versus non-neoplasm tissue
Age at NSCLC Diagnosis Tied to Odds of Targetable Phenotype
Younger age at diagnosis linked to increased frequency of targetable phenotype
c-Jun N-terminal Kinase Essential for HSV Reactivation
JNK signaling results in histone methyl-phospho switch on HSV lytic promoters
‘Suicide Gene Therapy’ Plus Radiation Effective in Prostate CA
Immunomodulatory in situ gene tx/IMRT with or without hormonal tx deemed feasible, safe
CYP2C19 Polymorphisms Impacts Citalopram Metabolism
CYP2C19*2 polymorphism seems to contribute to interindividual variability in CIT metabolism
MITF p.E318K Prevalence Similar, Regardless of CDKN2A
Mutation correlates with increased risk, especially for multiple primary melanoma, high nevi count
Cell-Free Circulating mtDNA Identifies Parkinson’s Disease
Reduced CSF ccf-mtDNA in patients with Parkinson's versus age-matched asymptomatic controls
