Tag: Genetics
Functionally ID’d Variants in HNF1A Linked to Diabetes Risk
Functionally characterized variants that reduce HNF-1A transcriptional activity strongly linked to diabetes
Similar Effects for PCSK9, HMGCR Variant-Mediated Lower LDL
Almost equivalent effects on cardiovascular events, diabetes per unit decrease in LDL-cholesterol level
Gene Mutation Linked to Early-Onset Parkinson’s Disease
Mutated GCH1 gene tied to 23 percent increased risk of Parkinson's; symptoms five years earlier
Methylation of Gene Panel May Help Predict Breast CA Survival
High cumulative methylation index linked to shorter median progression-free, overall survival
Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness
IH-induced exosomes from mice significantly promote TC1 malignant properties
Updated Index Predicts Survival in NSCLC With Brain Metastases
Significant prognostic factors include four factors from earlier index, plus EGFR and ALK alterations
Guidelines Developed for HER2 Testing in Gastroesophageal CA
Tumor specimens should be assessed for HER2 status before initiation of HER2-targeted therapy
Genetic Mortality Risk Can Be Attenuated by Lifestyle
Mortality up to 64 percent lower for those with low-risk lifestyle profile, independent of genetic risk
BACH2 Identified As Risk Locus for Addison’s Disease
Extended exome capture array shows BACH2 correlates with Addison's disease development
Smoking Ups Cancer Risk by Causing Distinct Cell Mutations
For every year of smoking a pack daily, 150 more mutations found in each lung cell
