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A genetic variant associated with opioid addiction may lead to personalized treatment for the condition

Gene May ID Patients Needing Higher Doses of Methadone

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Specific gene affects patients with African ancestry
Vulvar and vaginal melanomas have unique molecular features as compared to nongynecologic melanoma

Unique Molecular Features for Vulvar, Vaginal Melanomas

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BRAF most frequently mutated gene in VVMs, while NRAS mutations are rarely seen
The activity of certain genes are associated with premenstrual dysphoric disorder

Sex Hormone-Sensitive Gene Complex Implicated in PMDD

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Study adds to evidence of a biological cause of condition, researchers say
A panel of 88 single nucleotide polymorphisms can predict breast cancer risk

Panel of 88 SNPs Predicts Breast CA Risk in Women at High Risk

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SNP88 is independent of Tyrer-Cuzick model; improved prediction when combined multiplicatively
As many as one in six colorectal cancer patients under the age of 50 have genetic traits that greatly increase the risk of cancer

CRC in Patients Under 50 Often Caused by Genetic Mutations

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One in six diagnosed under 50 have at least one gene mutation that ups risk of cancer
The rate of germline BRCA1/2 and ATM mutations is significantly higher among patients with lethal prostate cancer and is an independent predictor of lethal prostate cancer

BRCA1/2, ATM Mutations ID Risk for Lethal Prostate Cancer

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After adjustment for covariates, mutation carrier remained independent predictor of lethal PCa
After actress Angelina Jolie's 2013 New York Times editorial that announced her preventive double mastectomy

BRCA Testing, Not Mastectomies, Up After Angelina Jolie Editorial

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More women tested for the BRCA genes but no corresponding increase in mastectomy rates
For patients with prostate cancer

Methylation of PITX2 DNA Feasible in Prostate Biopsies

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Can add prognostic information for risk assessment in presurgical diagnostic setting
Administration of cytotoxic T-cells targeting mutant KRAS G12D can induce tumor regression in metastatic colorectal cancer

Cytotoxic T-Cells Can Induce Metastatic CRC Regression

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Regression of tumors reported after administration of cytotoxic T-cells targeting mutant KRAS G12D
A single dose of an experimental gene therapy may benefit patients with hemophilia B

ASH: Single Dose of Gene Therapy Effective in Hemophilia B

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Small, preliminary trial suggests it may free hemophilia B patients from transfusions