Tag: Genetics
Smoking Alters Genetic Relationship with Parkinson’s
Smoking, HLA-DRB1 may be involved in common pathways, possibly neuroinflammation
Gene Expression Assay Classifies Diffuse Large B-Cell Lymphoma
Assay assesses expression of 21 markers, classifies most samples into expected subtype
Genetic Variant Tied to Prostate Cancer Outcomes
Time to metastasis, length of survival vary by number of HSD3B1 (1245C) variant alleles
Antisocial Behavior May Be Highly Polygenic
Promising loci that have sex-discordant associations with ASB identified
Scientists Support Genome Editing to Prevent Disease
Majority of survey respondents support gene editing to treat diseases but not human enhancement
Insulinomas May Hold Key to Diabetes Drug Development
Novel discovery of molecular pathways may reveal map to regenerate insulin-producing cells
Clinical Exome Sequencing Useful for Critically Ill Infants
Molecular diagnosis affects medical management in ~half of infants ID'd by clinical exome sequencing
Hypermutated ctDNA Linked to Checkpoint Inhibitor Response
Patients with high alteration number in variants of unknown significance had better outcomes
CYPC19*17 Allele May Influence Response to PPI Treatment
Kids with CYPC19*17 alleles without corresponding loss-of-function alleles have longer times with pH <4
Genotype-Guided Warfarin Dosing Cuts Adverse Events
Risk of composite of major bleeding, INR ≥4, VTE, death down for hip, knee arthroplasty patients
