Tag: Genetics
Genetic Variants Tied to Type 1 Diabetes Heterogeneity
TCF7L2 variants associated with single autoantibody, higher C-peptide, lower glucose
Researchers ID Microbiome Genes Tied to Asthma
Upper airway microbiota differs in children with asthma, asthma remission, and no asthma
LRRK2 Variants Linked to Lower Age at Onset of Parkinson’s
Participants with three risk variants of LRRK2 have significantly lower age at onset than noncarriers
PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors
Talazoparib caused regression in 5 patient-derived xenografts, 4 without germline BRCA1/2 mutations
Computed Tomography Features Vary Based on BRCA Status
Differences seen between BRCA-mutant versus BRCA wild-type high-grade serous ovarian cancer
Internists Key to Identifying Need for Genetic Counseling for Cancer
Complexity of genetic counseling for multigene testing has increased considerably
70-Gene Signature Impacts Treatment Decisions in Breast CA
70-GS linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay
Locus ID’d That Links Comorbid Alcohol Dependence, Depression
Robust association identified for SEMA3A locus in African American participants in two samples
Concerns Surround Use of Direct-to-Consumer Genetic Testing
Issues include limited knowledge about available tests, difficulty interpreting results, lack of oversight
HER3 Linked to Improved Survival With Panitumumab
Addition of panitumumab to irinotecan tied to improved survival in RAS wt advanced colorectal CA
