Tag: Genetics
Gene Therapy Found to Be Promising for β-Thalassemia
CD34+ cells transduced with BB305 vector lowered or eliminated need for red-cell transfusions
Males With BRCA Mutations Have Increased Risk of Certain Cancers
Increased incidence of malignant disease, specifically prostate, melanoma, pancreas, breast cancers
TFs Operate Across Gene Loci Within Disease Phenotypes
Epstein-Barr virus EBNA2 protein binds to multiple loci of genome, increasing risk of 7 serious diseases
Exercise Best Defense for Those at Genetic Risk for CVD
Benefit of exercise against cardiovascular disease notable even among those at high genetic risk
Genotype-Guided Antiplatelet Therapy Feasible, Effective
Genotype-guided therapy improves outcomes among CYP2C19 intermediate, poor metabolizers
apoE Aggregation May Impact apoE-Mediated Plaque Formation
Anti-human apoE-4 antibody preferentially binds unlipidated aggregated apoE over lipidated version
Complete Genome Sequence Can Be ID’d From Amniotic Fluid
Concordance of variant calls between cellular, cell-free DNA, with parental libraries >96 percent
Vigil Immunotherapy Tolerated Well for Recurrent Ovarian CA Tx
And, PARP 7 protein plays significant role; survival up with genetic mutations, higher expression levels
Fewer SIDS Cases Result From Genetic Heart Disease Causes
Findings may help prevent unnecessary genetic testing of surviving family members
Too Few Early Breast CA Patients Given Formal Genetic Counseling
43.5% of women with early-stage breast cancer with indications for risk evaluation get counseling
