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Klotho-VS heterozygosity is associated with a reduced risk for Alzheimer disease and β-amyloid burden in cognitively normal individuals aged older than 60 years who carry apolipoprotein e4

KL-VSHET+ Genotype Linked to Reduced Alzheimer Disease Risk

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Gene variant may be protective in those aged 60 to 80 years, cognitively normal, who carry APOE4
The novel coronavirus has been circulating in New York City for longer than previously believed and most cases can be traced back to Europe

COVID-19 Came to New York City From Europe, Not Asia

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Specific genetic codes in most New York City viral samples indicate they originated in Europe
Genetic testing is not better at predicting coronary heart disease risk compared with conventional risk factors

Genetic Testing Does Not Enhance Heart Disease Risk Prediction

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Polygenic risk score associated with heart disease events, not a better predictor than standard risk factors
Greater genetic predisposition for multiple sclerosis is associated with altered brain white matter development at an early age

Brain Changes From Multiple Sclerosis May Occur in Preteens

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Greater genetic predisposition for MS tied to imaging-observable changes in white matter in preteens
There seems to be a causal association between circulating insulin-like growth factor-1 concentrations and breast cancer

Causal Link Suggested for IGF-1 Concentrations, Breast Cancer

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In Mendelian randomization analyses, increase in genetically predicted IGF-1 linked to breast cancer
Among women with a history of gestational diabetes mellitus

Genetic Risk Linked to T2DM in Women With History of GDM

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Modest link found for genetic risk score with T2DM risk; link seems stronger for those with poorer dietary quality
In a cohort of unselected postmenopausal women with breast cancer

Genetic Mutations ID’d in Breast Cancer After Menopause

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3.55 percent of unselected postmenopausal women with breast cancer have pathogenic variants
Expansion of National Comprehensive Cancer Network hereditary cancer testing criteria to include all women diagnosed with breast cancer at ≤65 years would improve the sensitivity of detection of germline pathogenic variants

Genetic Testing Proposed for All Women ≤65 With Breast Cancer

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Expanded testing could increase detection of carriers for BRCA1/2, mutations in other predisposition genes
Receipt of molecularly matched therapy is associated with improved outcomes in patients with pancreatic cancer

Molecularly Matched Therapy Promising in Pancreatic Cancer

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Overall survival significantly longer for patients with actionable molecular alterations receiving matched tx
A proposed project to map the genes of 1 million people in New York living with or at risk for Alzheimer disease was announced Friday by Gov. Andrew Cuomo.

Alzheimer Disease Gene Mapping Project Proposed in New York State

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Governor says initiative will help researchers working to slow the progression of Alzheimer disease