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Next-generation sequencing can improve treatment efficacy and reduce hospitalization in children with drug-resistant epilepsy

Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

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In children with drug-resistant epilepsy, NGS can help establish diagnosis, improve treatment efficacy
The U.S. Food and Drug Administration has approved Epidiolex oral solution for treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome for patients age 2 years and older.

FDA Approves Epidiolex for Severe Forms of Epilepsy

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Cannabidiol oral solution approved for patients 2 and older with Lennox-Gastaut and Dravet syndromes
Women with epilepsy and no history of infertility have a similar likelihood of achieving pregnancy as peers without epilepsy

Epilepsy Does Not Appear to Affect Likelihood of Pregnancy

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Likelihood of achieving pregnancy, time to pregnancy similar in women with, without epilepsy
Although most adults with epilepsy report taking epilepsy medication

Too Few Adults Taking Epilepsy Meds Have Seizure Control

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Ninety percent of those with active epilepsy take meds; 44 percent of those report seizure control
The risk of unnatural death is increased among people with epilepsy

Increased Risk of Unnatural Death in People With Epilepsy

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Increased likelihood of dying of unnatural cause, unintentional injury or poisoning, or suicide
Early-life epilepsy should be treated with the same urgency as pediatric cancer

Early-Life Epilepsy Should Be Urgently Treated With EBM

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Best diagnostics and evidence-based treatments should be used from the start of the disease
Exposure to sodium valproate or a combination of antiepileptic drugs in utero is associated with worse attainment on national educational tests for 7-year-olds

Educational Attainment Down With In Utero Exposure to AEDs

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Exposure to sodium valproate, combo of antiepileptic drugs tied to worse attainment on national tests
For pediatric-onset treatment-resistant epilepsy

Cannabidiol Is Effective Add-On for Treatment-Resistant Epilepsy

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More effective than placebo for reducing seizure frequency, achieving seizure freedom
School performance is significantly lower for children with prenatal exposure to valproate

Prenatal Valproate Exposure May Impact School Performance

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Significant decrease in school performance for offspring exposed to valproate versus lamotrigine
Both focused attention and progressive muscle relaxation result in reductions in seizure frequency in patients with epilepsy

Stress Reduction May Help Reduce Epileptic Seizures

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Both focused attention and progressive muscle relaxation techniques cut seizures