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ASA: No Drop in Recurrent Stroke Seen With Apixaban After Cryptogenic Stroke

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No significant difference noted in recurrent stroke, symptomatic intracranial hemorrhage for patients receiving apixaban, aspirin

AHA: Apixaban Beneficial for Patients With Subclinical A-Fib

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Risk for stroke or systemic embolism lower with apixaban versus aspirin for patients with subclinical a-fib

Rates of Adverse Events Lower With Apixaban for A-Fib in Older Adults

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Apixaban the only direct oral anticoagulant linked to lower adverse event rates than warfarin for patients with atrial fibrillation across frailty levels

Among adults with atrial fibrillation

Apixaban Seems Safer Than Rivaroxaban for A-Fib

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Lower rates seen for ischemic stroke or systemic embolism, GI bleeding or intracranial hemorrhage
Many patients take over-the-counter products with potentially serious interactions with the direct-acting oral anticoagulant apixaban

Many Patients Take OTC Meds That May Interact With Apixaban

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Less knowledge about OTC products with potentially serious interactions linked to increased use
Apixaban therapy is cost-effective for atrial fibrillation from the perspective of the U.S. health care system

Apixaban Tx Cost in A-Fib Meets U.S. Norms for Reasonable Value

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Incremental cost of achieving longer life expectancy within accepted U.S. norm ($53,925/QALY)
For patients in the Apixaban for Reduction of Stroke and Other Thromboembolic Complications in Atrial Fibrillation trial

Usual Apixaban Dosing OK With One Dose-Reduction Criterion

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5 mg apixaban twice daily deemed safe, appropriate for those with one criterion in ARISTOTLE trial