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Drug-Drug Interactions Seen in 21.4 Percent of Children With Meds Exposure

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Adverse physiologic effect exposure rate highest for increased drug concentrations, CNS depression, QT interval prolongation

More Than 100 Experimental Treatments Have Been Used in the Fight Against COVID-19

Drug Interaction Checkers Could Have Caught Adverse Events

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More than three-quarters of COVID-19-associated drug-drug interactions could have been identified

Many Psychiatric Patients Are Getting Risky Drug Gabapentin ‘Off-Label’

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By Amy Norton HealthDay Reporter MONDAY, Nov. 22, 2021 (HealthDay News) -- Most prescriptions for the medication gabapentin are for unapproved uses -- and many...

Actionable Drug-Gene Interactions Common in U.K. Primary Care

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Actionable drug-gene interactions identified in 19.1 to 21.1 percent of all new prescriptions for 56 drugs

The efficacy of hormonal contraceptives may be reduced with use of antibiotics

Antibiotics May Reduce Efficacy of Hormonal Contraceptives

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Unintended pregnancies seven times more commonly reported with antibiotics than control medicines
Many patients take over-the-counter products with potentially serious interactions with the direct-acting oral anticoagulant apixaban

Many Patients Take OTC Meds That May Interact With Apixaban

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Less knowledge about OTC products with potentially serious interactions linked to increased use
Concurrent benzodiazepine use is associated with increased risk of opioid-related overdose

Risk of OD Highest for First Days of Opioid + Benzodiazepine Use

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Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use
Older adults report feeling confident that they know how to avoid drug interactions despite only 35 percent having spoken to someone about it in the past year

Many Seniors Have Not Discussed Avoiding Drug Interactions

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69 percent of patients see multiple doctors, 21 percent use multiple pharmacies, complicating issue
Concomitant use of valproic acid and meropenem is associated with a decrease in valproic acid plasma levels

Valproic Acid Plasma Levels Down With Concomitant Meropenem

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Concomitant use of meropenem linked to decrease in VPA plasma level, regardless of MEPM dose
Data mining can be used to discover unknown drug-drug interactions in cardiovascular medicine

Data From Clinical Registries Can ID Novel Drug Interactions

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Drug groups with known interactions rediscovered, new drug groups ID'd in warfarin-treated patients