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A DNA-based blood test appears to be more effective in detecting possible Down syndrome in unborn children than other screening methods

DNA-Based Blood Test More Accurate in ID of Down Sx

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But it won't eliminate need for invasive diagnostics such as amniocentesis
Exogenous progesterone seems to increase nuchal translucency

Exogenous Progesterone Increases Nuchal Translucency

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Increase also seen in women at low risk for fetal aneuploidies