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Donor-derived cell-free DNA is a potential biomarker that can predict allograft failure after lung transplantation

Plasma Marker Predicts Allograft Failure in Lung Transplant

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Average donor-derived cell-free DNA in highest tertile linked to increased risk for allograft failure
Cell-free DNA sequencing represents an advance in genomic medicine and has associated ethical challenges

Review Addresses Cell-Free DNA Sequencing in Pregnancy

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cfDNA testing for trisomy 21, 18, 13 recommended in pregnancy; no FDA oversight for testing
About one-quarter of adults with chronic kidney disease of unknown cause or familial nephropathy or hypertension have diagnostic mutations

Diagnostic Mutations ID’d in Chronic Kidney Disease Patients

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Whole-exome sequencing identified diagnostic mutations, including PARN mutations, in two patients

Downregulation of miR-126 Augments DNA Damage Response

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Reduced miR-126 levels in lungs from mice exposed to cigarette smoke, smokers' lung epithelial cells
Capacity to repair everyday damage to cell DNA could be impaired in people who work the night shift

Shift Work May Affect the Body’s Ability to Repair DNA Damage

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Lower levels of 8-hydroxydeoxyguanosine noted in the urine of those who worked at night
The first complete genome sequence of a sample of Zika virus derived from semen has been obtained

Complete Genome Sequence of Zika Isolated From Semen

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Many answers to questions about the virus may lie in the viral genome
Smoking cigarettes can leave a lasting imprint on human DNA

Smoking Appears to Have Broad, Long-Lasting Impact on DNA

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Changes related to disease found in more than 7,000 genes, though many 'recover' five years after quitting
Detection of circulating tumor DNA after resection of stage II colon cancer may identify patients at increased risk of recurrence

Circulating Tumor DNA May Help Predict Colon CA Recurrence

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Findings in patients after resection of stage II colon cancer
For men with metastatic prostate cancer

DNA-Repair Gene Mutations ID’d in Metastatic Prostate Cancer

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Prevalence of 11.8 percent for germline DNA-repair gene mutations presumed to be deleterious