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Use of oral fluconazole for treatment of vulvovaginal candidiasis in the first trimester of pregnancy is associated with musculoskeletal malformations

Musculoskeletal Malformations Up With Fluconazole in Pregnancy

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But no increase seen in conotruncal malformations, oral clefts with use of oral fluconazole in first trimester
Prenatal use of low-dose fluconazole is associated with cleft lip with cleft palate and d-transposition of the great arteries

Fluconazole Use May Raise Risk of Certain Birth Defects

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Study shows increased odds of cleft lip with cleft palate, d-transposition of the great arteries
Health care professionals should use caution when prescribing the oral antifungal drug fluconazole (Diflucan) during pregnancy because it may raise the risk of miscarriage

FDA: Fluconazole Linked to Increased Miscarriage Risk

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Agency recommends alternatives to fluconazole for mothers-to-be until its review is complete