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Transdermal estradiol plus intermittent micronized progesterone can prevent clinically significant depressive symptoms among euthymic perimenopausal and early postmenopausal women

Transdermal Estradiol May Help Prevent Depressive Symptoms

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Effects of TE, micronized progesterone seen in perimenopausal, early postmenopausal women
For patients with type 1 diabetes

Bidirectional Association for Depression, Dysglycemia in T1DM

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Depression increases risk of dysglycemia especially in first six months to one year of diagnosis
Transcranial direct current stimulation appears to be effective and safe as an add-on intervention for adults with bipolar depression

Transcranial Direct Current Stimulation Promising for Bipolar

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tDCS seems effective and safe for adults with bipolar depression receiving stable pharmacologic regimen
Esketamine seems to be efficacious and safe for patients with treatment-resistant depression

Esketamine Safe, Effective for Treatment-Resistant Depression

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Change in Montgomery-Åsberg Depression Rating Scale score superior for esketamine versus placebo
Girls with menarche at earlier ages may be at elevated risk for mental health issues in adolescence that carry into adult years

Early Menarche May Affect Mental Health in Adulthood

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Increased risk of depression, antisocial behaviors in adolescence may carry into adulthood
Parkinson's disease patients with depression have impaired white matter integrity

Impaired White Matter Integrity for Depression in Parkinson’s

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Reduced fractional anisotropy values in left anterior corona radiata, left cingulum of depressed patients
Adolescents with depression who are poor responders to treatment do not have more densely connected networks

Network Density Not Linked to Response in Teen Depression

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No significant association between higher network strength and poorer outcomes
Women at both extremes of the weight spectrum have low mean serum allopregnanolone

Mean Serum Allopregnanolone Low Across Weight Extremes

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Also tied to increased depression and anxiety severity, independent of body mass index
Heart rate variability and specific inflammatory biomarkers can differentiate major depressive disorder from depression in bipolar disorder

Simple ECG May Help Distinguish MDD From Bipolar Depression

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Higher low-frequency heart rate variability, lower levels of IL-10 and MCP-1 for major depression
For youths with depression

Treatment Trajectories Vary for Children With Depression

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Most common class got psychotherapy monotherapy, and had lowest incidence of attempted suicide