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Tezacaftor-ivacaftor or ivacaftor alone is effective for patients with cystic fibrosis who are heterozygous for the Phe508del deletion

Tezacaftor-Ivacaftor, Ivacaftor Alone Effective in CF

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And tezacaftor-ivacaftor effective for cystic fibrosis patients homozygous for CFTR Phe508del mutation
Reduced bacterial diversity in the upper and lower airways in infants with cystic fibrosis is associated with use of prophylactic antibiotics and younger age at sampling

Respiratory Microbiome May Influence Inflammation in CF

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Less diversity linked to lower IL-8 concentration, neutrophil count in infants with cystic fibrosis
or patients aged 6 to 11 years with cystic fibrosis homozygous for F508del-cystic fibrosis transmembrane conductance regulator

Lumacaftor, Ivacaftor Linked to Improved Lung Function in CF

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Findings in patients aged 6 to 11 years with cystic fibrosis homozygous for F508del-CFTR
The U.S. Food and Drug Administration says it has expanded approval for the cystic fibrosis drug Kalydeco (ivacaftor) to include 33 mutations of the disease

FDA OKs Kalydeco for Additional Mutations in Cystic Fibrosis

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Decision based on results of laboratory testing and previous clinical trials
New antibiotic therapy

New Antibiotic Tx Beneficial After Acute Lung Function Decline in CF

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Findings among children with cystic fibrosis treated either inpatient, outpatient
Life expectancy has increased for patients with cystic fibrosis

Cystic Fibrosis Patients in Canada Live Longer Than Those in U.S.

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Canadians with cystic fibrosis live about 10 years longer on average, researchers say
For children with cystic fibrosis

Ultrashort Echo-Time MRI IDs Lung Abnormalities in CF

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Strong correlations for CT and UTE MRI scores for pediatric CF patients for bronchiectasis, overall score
Mothers of infants with false-positive newborn bloodspot screening results for cystic fibrosis report immediate distress

Distress Over False-Positive Cystic Fibrosis Screen Not Lasting

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Despite immediate distress reported by mothers, psychosocial distress not detected in newborns
For patients with cystic fibrosis

Early Antibiotic Treatment Can Be Beneficial in Cystic Fibrosis

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Early treatment of Pseudomonas aeruginosa can eradicate bacteria, delay chronic colonization
Guidelines have been developed for the care of 2- to 5-year-old children with cystic fibrosis. The clinical practice guidelines were published online March 23 in Pediatrics.

Guidelines Developed for Preschoolers With Cystic Fibrosis

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Recommendations relate to routine surveillance for lung disease, therapeutics, nutritional and GI care