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Tag: Crohn’s Disease

Marketplace introduction of infliximab has not resulted in reductions in the population rates of inflammatory bowel disease-related hospitalizations or intestinal resections or colectomies

Infliximab Introduction Has Not Cut IBD-Related Hospitalizations

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Introduction of infliximab did not lead to drop in hospitalization, intestinal resection, colectomy
A new test can predict the course of inflammatory bowel disease in patients

Biomarker Test Predicts Mild, Serious IBD in Newly Diagnosed

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Test based on genetic signature of CD8 T cells during active disease
Low body mass index among men entering adult life is associated with an increased incidence of Crohn disease and ulcerative colitis up to 40 years later

In Men, Low BMI Tied to Later Inflammatory Bowel Disease

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Risk lasts through 40 years of adulthood for underweight adolescent men
A post hoc analysis of data from a randomized trial shows no difference between older and younger patients for the safety and efficacy of early combined immunosuppression therapy compared with conventional management for Crohn disease

Older Patients With Crohn Disease May Benefit From Early Combo Tx

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Early step-up combo therapy includes tumor necrosis factor-α antagonist plus an antimetabolite
For children with Crohn disease

Malnutrition Ups Risk of Postop Issues in Pediatric Crohn Disease

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In propensity-matched analysis, mild, severe malnutrition linked to elevated odds of complications
CT-P13

Reference Infliximab, Biosimilar Equivalent for Crohn’s Disease

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CT-P13 is equivalent to reference product in primary outcome; no difference in safety outcomes
Psoriasis appears to be significantly associated with inflammatory bowel disease

Psoriasis Linked to Increased Risk for Inflammatory Bowel Disease

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Significant associations observed between psoriasis and risk for Crohn's disease, ulcerative colitis
Loss to follow-up is common with inflammatory bowel disease

Loss to Follow-Up Common With IBD, But Many Have Flare-Ups

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Predictors of follow-up loss are long travel time and low C-reactive protein levels at diagnosis
Higher levels of Candida tropicalis

Higher Levels of Fungus ID’d in Patients With Crohn’s

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Patients with Crohn's had higher levels of Candida tropicalis, Escherichia coli, Serratia marcenscens
Long-term use of azathioprine is associated with a better disease course in patients with early Crohn's disease

Azathioprine Appears to Improve Disease Course in Early Crohn’s

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Prior bowel resection, smoking, and low hemoglobin tied to Crohn's-related surgery