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For patients with chronic obstructive pulmonary disease

CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start

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New use of long-acting β2-agonists, antimuscarinic antagonists tied to higher CVD risk in first 30 days
New evidence regarding safety is spurring the U.S. Food and Drug Administration to remove a Boxed Warning from certain inhaled medications used to treat asthma and chronic obstructive pulmonary disease.

FDA Removes Boxed Warning From Certain Asthma Medications

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Decision applies to long-acting beta agonists used in combination with inhaled corticosteroids
Individuals with rheumatoid arthritis have an increased risk of incident chronic obstructive pulmonary disease hospitalization compared with those in the general population

RA Associated With Higher Risk of COPD Hospitalization

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Risk is 47 percent higher in RA patients than general population after adjustment for confounders
Treatment with long-acting muscarinic antagonists plus long-acting β-agonists is associated with fewer exacerbation events in patients with chronic obstructive pulmonary disease

LAMA Plus LABA Tied to Fewer Exacerbations in Stable COPD

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Also might result in greater improvement in FEV1 than LABA plus corticosteroids
Patients with chronic obstructive pulmonary disease with an eosinophilic phenotype may benefit from mepolizumab

Mepolizumab Beneficial in COPD With Eosinophilic Phenotype

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Lower annual rate of moderate, severe exacerbations for patients receiving 100 mg mepolizumab
Statin use is associated with a reduced risk of all-cause and pulmonary-related mortality in patients with chronic obstructive pulmonary disease

Statins Tied to Reduced Mortality Risk in COPD

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Statin exposure associated with lower all-cause, pulmonary mortality
Airway mucin concentrations may be a marker for chronic bronchitis

Airway Mucin Concentrations May Help Predict Chronic Bronchitis

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Mean total mucin concentrations up in smokers with severe COPD, those with respiratory exacerbations
Tiotropium appears to be effective at improving lung function in patients with mild to moderate chronic obstructive pulmonary disease

Tiotropium Effective in Mild to Moderate COPD

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Daily inhaled dose tied to improvements in FEV1 compared to placebo
For patients with ST-segment elevation myocardial infarction

Worse LV Global Longitudinal Strain for STEMI With COPD

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Patients with versus without COPD have more impaired left ventricular global longitudinal strain
For patients with chronic obstructive pulmonary disease

Once-Daily Triple-Tx Improves Lung Function, HRQoL in COPD

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Significantly improved FEV1 and St. George's Respiratory Questionnaire scores