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A second COVID-19 vaccine trial was paused on Monday after an unexplained illness surfaced in one of the trial's volunteers.

Second COVID-19 Vaccine Trial Paused for Unexplained Illness

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Johnson & Johnson stopped its COVID-19 vaccine trial, which began phase 3 testing last month
Older adults are likely to be excluded from many COVID-19 clinical trials and all vaccine trials

Older Adults Likely to Be Excluded From COVID-19 Trials

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Fifty percent of phase 3 clinical trials and 100 percent of vaccine trials at risk for excluding older adults
New drug applications for prescription opioids for pain have been based on pivotal trials of short or intermediate duration

New FDA Applications for Opioids Often Based on Short Trials

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Most products for treating chronic pain approved based on narrowly defined populations of patients
The effect of gender is still largely ignored in scientific studies

Most Studies Still Fail to Analyze Data by Sex

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However, women are significantly better represented in clinical trials
African-Americans are underrepresented in clinical trials leading to approval of cancer medications

African-American Participation Inadequate in Cancer Drug Trials

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Consistent underrepresentation seen in clinical trials evaluating medications across major cancer types
Many clinical trials for COVID-19 treatments are limited by their design

Many of the Initial COVID-19 Treatment Trials Poorly Designed

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One-third of trials do not include clinical end points; 97 randomized trials were open-label design
Prostate cancer clinical trial participants are overwhelmingly white

Prostate Cancer Trial Participants Overwhelmingly White

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Since 1990, proportion of white participants in prostate cancer clinical trials has remained >80 percent
Nearly half of cancer research has been stopped due to the COVID-19 pandemic

COVID-19 Pandemic Slowing Cancer Research

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Findings based on survey of American Cancer Society research grantees
Just one in five pediatric cancer patients enroll in clinical trials

Fewer Children Enrolling in Pediatric Cancer Trials

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Adolescent and young adult cancer patients underrepresented in clinical trials
The impact of COVID-19 on oncology clinical trials and long-term implications are discussed in a study and recommendations published in JCO Oncology Practice.

Impact of COVID-19 on Oncology Clinical Trials Discussed

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Recommendations for sustaining cancer care access include permanent expanded support for telehealth