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Many clinical trials for COVID-19 treatments are limited by their design

Many of the Initial COVID-19 Treatment Trials Poorly Designed

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One-third of trials do not include clinical end points; 97 randomized trials were open-label design
Prostate cancer clinical trial participants are overwhelmingly white

Prostate Cancer Trial Participants Overwhelmingly White

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Since 1990, proportion of white participants in prostate cancer clinical trials has remained >80 percent
Nearly half of cancer research has been stopped due to the COVID-19 pandemic

COVID-19 Pandemic Slowing Cancer Research

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Findings based on survey of American Cancer Society research grantees
Just one in five pediatric cancer patients enroll in clinical trials

Fewer Children Enrolling in Pediatric Cancer Trials

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Adolescent and young adult cancer patients underrepresented in clinical trials
The impact of COVID-19 on oncology clinical trials and long-term implications are discussed in a study and recommendations published in JCO Oncology Practice.

Impact of COVID-19 on Oncology Clinical Trials Discussed

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Recommendations for sustaining cancer care access include permanent expanded support for telehealth
High-dosage chloroquine diphosphate has potential safety hazards when used as adjunctive therapy for patients hospitalized with severe COVID-19

Adding High-Dose Chloroquine Not Advised for Severe COVID-19

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High-dose versus low-dose group had higher lethality until day 13, more instances of QTc interval >500 ms
Inconclusive findings from a study investigating the antiviral drug remdesivir as a treatment for COVID-19 were posted to the World Health Organization website "prematurely

Premature Posting of Remdesivir Findings Were ‘Inconclusive’

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Due to low enrollment, study was 'underpowered to enable statistically meaningful conclusions'
A number of institutions this week announced their participation in an international clinical drug trial evaluating the safety and efficacy of remdesivir in hospitalized patients with the novel coronavirus 2019.

Enrollment Begins in NIH-Sponsored Trial of Remdesivir for COVID-19 Patients

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Institutions also announce enrollment in study evaluating efficacy of sarilumab for hospitalized COVID-19 patients
Most articles published between 2014 and 2019 discussing the characteristics

Author Conflicts of Interest May Influence Cannabidiol Conclusions

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Supportive conclusions seen in more studies with versus without CBD-related industry funding
Men still dominate participation in cardiovascular clinical trials

Fewer Women in Cardiovascular Trials, but Representation Improving

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Representation of women varies with disease and trial characteristics, but overall, men still dominate