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Drugmakers AstraZeneca and Johnson & Johnson are ready to resume paused COVID-19 vaccine trials after health scares

AstraZeneca, J&J Resume U.S. COVID-19 Vaccine Trials

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U.S. Food and Drug Administration authorized the restart after reviewing all safety data
The first company to start a phase 3 trial of a COVID-19 vaccine reached its target of enrolling 30

U.S. COVID-19 Vaccine Trial Enrolls 30,000

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Moderna says it is on track to apply for FDA approval to market the vaccine in early December
Long-term survival analysis shows that patients with earlier initiation of sodium phenylbutyrate-taurursodiol treatment for amyotrophic lateral sclerosis have longer median overall survival

Investigational Drug May Prolong Survival in Patients With ALS

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Median survival 6.5 months longer with initiation of PB-TURSO treatment compared with placebo
British scientists are infecting healthy volunteers with COVID-19

Scientists to Infect Volunteers With COVID-19 in Challenge Trial

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Challenge trials have long history, going back to development of smallpox vaccine in 1796
Upadacitinib is superior to abatacept for patients with rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs

Upadacitinib Tops Abatacept for RA Refractory to DMARDs

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Superior for mean change in composite DAS28-CRP values and remission, but more adverse events seen
Manualized psychotherapy interventions combined with pharmacotherapy seem beneficial for bipolar disorder

Pharmacotherapy, Psychotherapy Combo Best for Bipolar Disorder

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Manualized treatments linked to significantly reduced recurrence rates versus control treatments
Ertugliflozin is noninferior to placebo with respect to major adverse cardiovascular events among patients with type 2 diabetes and atherosclerotic cardiovascular disease

Ertugliflozin Noninferior for CV Outcomes in T2DM With ASCVD

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Ertugliflozin is noninferior to placebo for the primary end point of major adverse cardiovascular events
A study to assess whether certain approved or experimental drugs are effective against COVID-19 and warrant testing in large clinical trials has been launched by the U.S. National Institutes of Health (NIH).

NIH Launches Trial of Antibody Drugs Against COVID-19

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The phase 2 trial will assess effectiveness of monoclonal antibodies in conjunction with remdesivir
Enrollment in a study testing an experimental antibody therapy against COVID-19 has been paused by independent monitors.

COVID-19 Antibody Treatment Study Paused

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ACTIV-3 study, testing use of an antibody therapy with remdesivir, paused 'out of an abundance of caution'
More than half of patients offered participation in cancer clinical trials are willing to participate

More Than Half of Cancer Patients Willing to Enroll in Clinical Trials

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Participation rates similar for Black and White patients, treatment and cancer control trials