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Tag: Clinical Trials

The Affordable Care Act may have enabled more privately insured patients to enroll in clinical trials for cancer treatments

More Patients Enrolled in Cancer Trials Under ACA

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Insurer approval rates rose from ~85 percent before Affordable Care Act to ~95 percent after
Many men in the control arm of a screening trial undergo prostate-specific antigen testing during 15 years of follow-up

PSA Testing Frequency High in Control Arm of Screening Trial

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Over 15 years of follow-up, considerable proportion of men undergo prostate-specific antigen testing
For development of oncology drugs in Japan

Strategies Compared for Cancer Medication Submission Lags

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Shorter submission lag for global trial, early-initiation bridging strategy vs late-initiation strategy
Open-label placebos are associated with a positive effect compared with no treatment in a variety of clinical conditions

Positive Clinical Effects Seen for Placebos Without Deception

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Findings based on five studies involving patients with IBS, depression, allergic rhinitis, back pain, ADHD
Over the past 60 years

ASCO: SWOG Trials Have Had Considerable Impact on Cancer

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Estimated 3.34 million life-years gained through 2015 from 23 positive SWOG treatment trials
Compared with no treatment

Open-Label Placebos Seem to Have Positive Clinical Effect

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Review including data from five trials shows positive effect of non-deceptive placebos
Conventional clinical trials are unable to detect clinically important heterogeneity in intensive blood pressure treatment effects

Conventional Trials Can’t Detect Heterogeneity in BP Tx Effects

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Clinically important heterogeneity in intensive BP tx effect can be ID'd in sequential randomization trials
Many randomized clinical trials involving spinal manipulative therapy do not report adverse events

Many Spinal Manipulation Trials Don’t Report Adverse Events

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Significant increase in reporting of adverse events post-CONSORT statement of 2010
Many cancer patients hold unrealistic hopes when they decide to join early-stage clinical trials of experimental treatments

Cancer Patients Have Unrealistic Hopes Entering Clinical Trials

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Study finding is a red flag, researcher says
Few surgical studies include men and women equally

Minority of Surgical Studies Include Men, Women Equally

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About one-third of articles analyze data by sex; fewer include discussion of sex-based results