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Tag: Clinical Trials

Open-label placebos are associated with a positive effect compared with no treatment in a variety of clinical conditions

Positive Clinical Effects Seen for Placebos Without Deception

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Findings based on five studies involving patients with IBS, depression, allergic rhinitis, back pain, ADHD
Over the past 60 years

ASCO: SWOG Trials Have Had Considerable Impact on Cancer

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Estimated 3.34 million life-years gained through 2015 from 23 positive SWOG treatment trials
Compared with no treatment

Open-Label Placebos Seem to Have Positive Clinical Effect

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Review including data from five trials shows positive effect of non-deceptive placebos
Conventional clinical trials are unable to detect clinically important heterogeneity in intensive blood pressure treatment effects

Conventional Trials Can’t Detect Heterogeneity in BP Tx Effects

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Clinically important heterogeneity in intensive BP tx effect can be ID'd in sequential randomization trials
Many randomized clinical trials involving spinal manipulative therapy do not report adverse events

Many Spinal Manipulation Trials Don’t Report Adverse Events

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Significant increase in reporting of adverse events post-CONSORT statement of 2010
Many cancer patients hold unrealistic hopes when they decide to join early-stage clinical trials of experimental treatments

Cancer Patients Have Unrealistic Hopes Entering Clinical Trials

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Study finding is a red flag, researcher says
Few surgical studies include men and women equally

Minority of Surgical Studies Include Men, Women Equally

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About one-third of articles analyze data by sex; fewer include discussion of sex-based results
Only about half of trials registered at ClinicalTrials.gov are listed in the largest data-sharing repository

Many Clinical Trials Are Not Listed in Data-Sharing Repository

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Fifty-three percent of randomized clinical trials were listed at Clinical Study Data Request website
Just four in 10 Americans have a positive impression of clinical trials

Many Americans Have Reservations About Clinical Trials

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Only 40 percent had favorable view of these studies, but number rose when they received more info
Precision cancer treatment that's guided by genetic clues from the patient's own tumor appears to improve outcomes

ASCO: Phase I Cancer Drug Trials Benefit From Precision Medicine

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Better outcomes for patients whose treatment is selected based on molecular characteristics of tumor