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Tag: Clinical Trials

Intervention uptake was insufficient to allow evaluation of its impact in a pragmatic trial designed to assess the effect of longer hemodialysis duration on death and other outcomes; the findings from the Time to Reduce Mortality in ESRD trial were published online April 18 in the Journal of the American Society of Nephrology.

Trial Results Unclear for Benefit of Longer Hemodialysis Sessions

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Intervention uptake not sufficient to assess impact of longer hemodialysis sessions on patient outcomes
In certain cases

Genetic Research Results May Warrant Updates to Participants

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Participants should be recontacted in some cases of new information about variant, newly ID'd variants
Only a small proportion of recommendations in major cardiovascular society guidelines are supported by evidence from multiple randomized controlled trials (RCTs) or a single large RCT

ACC: Robust Evidence Lacking for Many Cardiovascular Guidelines

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Few recommendations in cardiovascular society guidelines supported by evidence from multiple RCTs
Authors of a paper recently published in the Journal of the American Geriatrics Society describe factors that influenced the new National Institute of Health policy that requires funded scholars to eliminate arbitrary age limits in their work.

Influences on New NIH Policy for Age Limits in Research Explored

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'Inclusion Across the Lifespan' policy eliminates non-risk-justified age limits on research participants
Structural and clinical barriers prevent most cancer patients from participating in clinical trials

Structural, Clinical Barriers Prevent Cancer Trial Participation

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Trial unavailable at patients' institution 55.6 percent of the time; 21.5 percent of patients ineligible
Many systematic review protocols in the International Prospective Register of Systematic Reviews do not include adverse event reporting

Many Systematic Reviews Do Not Fully Report Adverse Events

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Of 146 protocols analyzed, 65 percent fully reported adverse events as intended by the protocol
For cancer patients

Comorbidities Adversely Linked to Cancer Trial Participation

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Reduction in trial discussions, trial offers, trial participation seen with one or more comorbidities
During a median follow-up of 6.8 years

Few Mandatory Pediatric Postmarketing Studies Completed

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33.8 percent of mandatory pediatric postmarketing studies completed during 6.8 years of follow-up
There is a high prevalence of financial conflicts of interest among authors of clinical practice guidelines related to high-revenue medications and in gastroenterology

Financial Conflicts of Interest Prevalent Among CPG Authors

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Two studies show high prevalence among authors of guidelines on high-dollar meds, in gastroenterology
A lack of understanding of terminology

Barriers to Prostate Cancer Research in Black Men Identified

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Mistrust, lack of knowledge, unfavorable attitudes are barriers to genomic testing, study participation