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Authors of a paper recently published in the Journal of the American Geriatrics Society describe factors that influenced the new National Institute of Health policy that requires funded scholars to eliminate arbitrary age limits in their work.

Influences on New NIH Policy for Age Limits in Research Explored

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'Inclusion Across the Lifespan' policy eliminates non-risk-justified age limits on research participants
Structural and clinical barriers prevent most cancer patients from participating in clinical trials

Structural, Clinical Barriers Prevent Cancer Trial Participation

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Trial unavailable at patients' institution 55.6 percent of the time; 21.5 percent of patients ineligible
Many systematic review protocols in the International Prospective Register of Systematic Reviews do not include adverse event reporting

Many Systematic Reviews Do Not Fully Report Adverse Events

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Of 146 protocols analyzed, 65 percent fully reported adverse events as intended by the protocol
For cancer patients

Comorbidities Adversely Linked to Cancer Trial Participation

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Reduction in trial discussions, trial offers, trial participation seen with one or more comorbidities
During a median follow-up of 6.8 years

Few Mandatory Pediatric Postmarketing Studies Completed

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33.8 percent of mandatory pediatric postmarketing studies completed during 6.8 years of follow-up
There is a high prevalence of financial conflicts of interest among authors of clinical practice guidelines related to high-revenue medications and in gastroenterology

Financial Conflicts of Interest Prevalent Among CPG Authors

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Two studies show high prevalence among authors of guidelines on high-dollar meds, in gastroenterology
A lack of understanding of terminology

Barriers to Prostate Cancer Research in Black Men Identified

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Mistrust, lack of knowledge, unfavorable attitudes are barriers to genomic testing, study participation
Dozens of scientific papers from the laboratory of well-known heart researcher Piero Anversa contain fraudulent data

Harvard: Heart Researcher’s Papers Contain Fraudulent Data

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31 scientific publications from the laboratory of Piero Anversa contain falsified and/or fabricated data
Accepted manuscripts for observational studies have better adherence to the Strengthening the Reporting of Observational Studies in Epidemiology checklist compared with rejected manuscripts

Accepted Manuscripts Meet More Criteria for Research Reporting

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Certain items, such as objectives, translation of risk poorly reported in most observational research
Industry employees are often involved in the design

Industry-Funded Trials Often Involve Employees in Studies

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Many trials published in high-impact journals involve funder, academic author in study design, reporting