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Tag: Clinical Trials

In a scientific expert panel consensus document

Guidance Issued for Research Use of Cardiac MRI After MI

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Index CMR should be performed five ± two days after reperfusion
Common conditions are keeping many patients from participating in knee cartilage research studies

Many Patients Excluded From Knee Cartilage Research Studies

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Authors say trial results could be much more robust, reflective of patient population with greater inclusion
For cancer drugs ultimately approved by the U.S. Food and Drug Administration

Approving Children’s Cancer Drugs Takes 6.5 Years Longer

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Gap reflects time from first clinical trial in humans to the first trial in children
The International Pediatric Multiple Sclerosis Study Group has updated standards for future clinical trials in pediatric multiple sclerosis; the new recommendations were published in the May 28 issue of Neurology.

Recommendations Developed for Pediatric Multiple Sclerosis Trials

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Biological rationale exists for using treatments proven efficacious in adults with MS for pediatric MS
More than 60 percent of patients with lupus report that the disease has a large effect on their emotional and mental well-being

Lupus Affects Emotional, Mental Well-Being of Patients

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Most patients report not having participated in a lupus clinical trial, despite interest
Efforts are needed to ensure all completed large trials are reported

Efforts Needed to Ensure Publication of All Trials

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67 trials ID'd that were unreported for median of nine years after completion, with 87,883 participants
An evaluation of funding cycles (7 through 14) from the Patient-Centered Outcomes Research Institute shows that relatively low levels of primary care research studies are funded

Primary Care Constitutes Minority of Research Funded by PCORI

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Both the number of studies and percentage of funding for primary care low
Intervention uptake was insufficient to allow evaluation of its impact in a pragmatic trial designed to assess the effect of longer hemodialysis duration on death and other outcomes; the findings from the Time to Reduce Mortality in ESRD trial were published online April 18 in the Journal of the American Society of Nephrology.

Trial Results Unclear for Benefit of Longer Hemodialysis Sessions

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Intervention uptake not sufficient to assess impact of longer hemodialysis sessions on patient outcomes
In certain cases

Genetic Research Results May Warrant Updates to Participants

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Participants should be recontacted in some cases of new information about variant, newly ID'd variants
Only a small proportion of recommendations in major cardiovascular society guidelines are supported by evidence from multiple randomized controlled trials (RCTs) or a single large RCT

ACC: Robust Evidence Lacking for Many Cardiovascular Guidelines

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Few recommendations in cardiovascular society guidelines supported by evidence from multiple RCTs