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Tag: Clinical Trials

Most articles published between 2014 and 2019 discussing the characteristics

Author Conflicts of Interest May Influence Cannabidiol Conclusions

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Supportive conclusions seen in more studies with versus without CBD-related industry funding
Men still dominate participation in cardiovascular clinical trials

Fewer Women in Cardiovascular Trials, but Representation Improving

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Representation of women varies with disease and trial characteristics, but overall, men still dominate
For patients with refractory chronic cough or unexplained chronic cough

Gefapixant Promising for Relief of Unexplained Chronic Cough

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Cough frequency significantly reduced after 12 weeks of gefapixant 50 mg versus placebo in phase 2b study
Two experimental drugs do not appear to slow memory loss or mental decline in patients in the early stages of a rare

Two Experimental Drugs for Rare, Inherited Alzheimer Disease Disappoint

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Both drugs designed to target and neutralize amyloid beta in the brain
Adherence to randomized clinical trial visits is associated with visual acuity in individuals with neovascular age-related macular degeneration

Visit Adherence, Visual Acuity Linked in Macular Degeneration

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Late, very late groups saw fewer letters than patients in on-time group for two measures of visit adherence
Compliance with the U.S. Food and Drug Administration Amendments Act of 2007 is low

Fewer Than Half of Clinical Trials Comply With Reporting Laws

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Compliance with Food and Drug Administration Amendments Act of 2007 low, not improving
Institutional imaging cores may help provide unbiased and reproducible measurements and enable a leaner workflow in assessing tumor measurements for patients participating in clinical trials

New Workflow Could Improve Imaging Assessment in Research

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Use of a tumor response assessment core can avoid potential bias by medical oncologists in oncology trials
Among children with Hodgkin lymphoma enrolled in phase III trials

Survival Worse for Nonwhite Children With Hodgkin Lymphoma

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Risk for postrelapse mortality 2.7-, 3.5-fold higher for Hispanics, non-Hispanic blacks versus whites
Men should be included in clinical trials of new breast cancer treatments

FDA: Men Should Be Included in Breast Cancer Clinical Trials

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Draft guidance that men be included in breast cancer trials issued by the FDA on Aug. 26
More than half of randomized controlled trials with statistically nonsignificant findings for the primary end points published in psychiatry and psychology journals have spin in the abstract

Reporting of Results Often Biased in Psychiatry, Psychology Trials

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Fifty-six percent of trials had spin in abstract; no correlation seen for industry funding with spin