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Semaglutide May Reduce Craving in Alcohol Use Disorder

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Phase 2 trial shows significant reduction in drinks per drinking day and weekly alcohol craving

One in Six Patients in Phase 2 Cancer Trials Receive Drug When Eventually Approved

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Proportion increases when considering off-label use but drops when considering drugs with substantial clinical benefit

AI-Assisted Screening Tool Speeds Trial Eligibility Determination

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Implementing AI-assisted screening tool enhances clinical trial efficiency, expedites screening process

Tecovirimat No Aid for Time to Lesion Resolution With Mpox

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Additionally, interim analysis shows that the antiviral is safe but has no effect on pain among adults with mild-to-moderate clade II mpox

About One-Third Eligible for Weight Loss Drugs Meet Trial Exclusion Criteria

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Most common exclusion criteria were major depressive disorder, malignant neoplasms, liver disease, uncontrolled HTN

Progression-Free Survival Improved With Nivolumab + AVD in Hodgkin Lymphoma

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Longer progression-free survival seen with nivolumab + doxorubicin, vinblastine, and dacarbazine (AVD) versus brentuximab vedotin + AVD

2008 to 2022 Saw Rise in Industry-Sponsored Adult Cancer Clinical Trials

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From 2018 to 2022, industry-to-federally sponsored trial ratio was 8.1

Once-Weekly Efsitora Noninferior to Degludec for Type 2 Diabetes

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Once-weekly efsitora noninferior to once-daily degludec for decrease in mean glycated hemoglobin level

Quadruple Single Pill Superior for Resistant Hypertension

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Reductions seen in mean office sitting systolic BP and sitting diastolic BP and in mean 24-hour ambulatory systolic BP

Depemokimab Cuts Exacerbation Rate in Eosinophilic Asthma

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Annualized rate of exacerbations reduced across two randomized trials in severe asthma with eosinophilic phenotype