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Tag: Chemotherapy

For heavily pre-treated patients with relapsed/refractory multiple myeloma

VDT PACE Effective in Relapsed, Refractory Multiple Myeloma

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Minimal response or more in 68.4 percent of patients, partial response or more in 54.4 percent
The adoption of state oral chemotherapy parity laws has improved financial protection for many patients

Oral Chemotherapy Parity Laws Offer Some Financial Protection

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Decrease in estimated out-of-pocket spending at the 25th, 50th, 75th percentiles; increase at 90th, 95th
The 70-gene signature assay affects treatment decisions among physicians treating patients identified as being at intermediate risk with the 21-gene assay

70-Gene Signature Impacts Treatment Decisions in Breast CA

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70-GS linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay
Researchers may have uncovered the mechanism for chemotherapy-induced peripheral neuropathy related to paclitaxel

Mechanism ID’d for Chemo-Related Peripheral Neuropathy

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Paclitaxel triggers CIPN in part by altering IP3 receptor phosphorylation, intracellular calcium flux
Ramucirumab appears to be safe and effective for the treatment of advanced gastric cancer

Ramucirumab Shows Promise in Care of Advanced Gastric Cancer

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In two separate trials, hazard ratios for overall survival favor treatment with ramucirumab
The strongest evidence for benefit of cannabinoids in children is for chemotherapy-induced nausea and vomiting

Limited Evidence of Benefit for Medical Cannabinoids in Children

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Strongest evidence for benefit in chemo-induced nausea, vomiting; other uses need more evidence
Cryotherapy may be useful for preventing symptoms of chemotherapy-induced peripheral neuropathy

Cryotherapy May Prevent Chemo-Induced Neuropathy

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Breast cancer patients on paclitaxel had lower incidence of peripheral neuropathy with cryotherapy
Patients with severe neurotoxicity after infusion of CD19-targeted chimeric antigen receptor-modified T cells have evidence of endothelial activation

Neurotoxicity Characterized After Infusion of CD19 CAR-T Cells

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Patients with severe neurotoxicity have endothelial activation, increased BBB permeability
For patients with follicular lymphoma

PFS Up With Obinutuzumab-Based Tx in Follicular Lymphoma

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Induction, maintenance treatment with obinutuzumab-based chemo beats rituximab
For patients with stage III non-small-cell lung cancer

ASTRO: Standard-Dose CRT Beats Higher Dose in Stage III NSCLC

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Significantly improved five-year overall survival rates with 60 Gy chemoradiation tx versus high-dose