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Survivors of childhood Hodgkin lymphoma remain at increased risk for developing subsequent malignant neoplasms

Childhood Hodgkin Lymphoma Survivors at Risk for Later Cancers

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Survivors have 14-fold increased risk for developing a solid subsequent malignant neoplasm
The risks for therapy-related myelodysplastic syndrome or acute myeloid leukemia are elevated after chemotherapy use for solid tumors

Myelodysplastic Syndrome/AML Risk Increased After Chemo

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Since 2000, risks for therapy-related myelodysplastic syndrome, AML up after chemo for solid cancers
For patients with resected pancreatic cancer

Modified-FOLFIRINOX Beneficial in Resected Pancreatic Cancer

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Disease-free, overall survival significantly longer compared with gemcitabine, but more adverse events
For treatment of human papillomavirus-positive low-risk oropharyngeal cancer

Cisplatin Superior to Cetuximab for HPV+ Oropharyngeal Cancer

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Toxicity similar in two treatment groups at 24 months, but worse tumor control with cetuximab
Among patients with cancer starting chemotherapy who are at intermediate-to-high risk

Apixaban Prevents VTE in Cancer Patients Initiating Chemotherapy

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Major bleeding occurred in more apixaban-treated than control patients
For patients with residual invasive disease after neoadjuvant chemotherapy including a taxane and trastuzumab

SABCS: T-DM1 Cuts Recurrent Invasive HER2+ Breast CA Risk

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Risk reduced with trastuzumab emtansine in those with residual invasive dz at sx after neoadjuvant chemo
For patients with CD30-positive peripheral T-cell lymphoma

ASH: A+CHP Bests CHOP for Peripheral T-Cell Lymphoma

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Median progression-free survival improved with A+CHP vs CHOP; similar incidence of adverse events
Delaying initiation of adjuvant chemotherapy in triple-negative breast cancer patients more than 30 days after surgery is associated with a decrease in survival

SABCS: Delaying Chemo Lowers Survival in Triple-Neg Breast CA

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Findings show delaying chemo over 30 days postsurgery lowers triple-negative breast cancer survival
The U.S. Food and Drug Administration recently announced the approval of Daurismo (glasdegib) tablets for use in combination with a low dose of the chemotherapy cytarabine to treat newly diagnosed acute myeloid leukemia. The treatment is indicated for patients aged 75 years or older who have comorbidities that may prevent the use of intensive chemotherapy.

FDA Approves New Treatment for Acute Myeloid Leukemia

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Randomized clinical trial showed significant improvement in overall survival with Daurismo
For premenopausal women with stage I to IIIA estrogen receptor-negative

Improved Long-Term Pregnancy Outcomes for Goserelin + Chemo

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Findings seen in premenopausal women with stage I to IIIA hormone receptor-negative breast cancer