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Tag: Chemotherapy

For patients with metastatic colorectal cancer

Continuing Full Induction Regimen Not Beneficial in Metastatic CRC

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Maintenance therapy shows benefit versus observation in terms of PFS but not overall survival
Adding tucatinib to trastuzumab and capecitabine is associated with improved progression-free and overall survival among heavily pretreated patients with human epidermal growth factor receptor 2-positive metastatic breast cancer

SABCS: Addition of Tucatinib Ups Survival in HER2+ Metastatic Breast Cancer

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In heavily pretreated patients, adding tucatinib versus placebo improves overall, progression-free survival
Positron emission tomography-directed therapy results in excellent outcomes for patients with stage I/II diffuse large B-cell lymphoma

ASH: PET Helps Tailor Therapy in Limited-Stage DLBCL

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Most patients had negative PET scan and completed one additional R-CHOP cycle without radiation
Endocrine therapy reduces the quality of life of breast cancer patients

Endocrine Therapy Lowers QOL for Breast Cancer Patients

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Effects of chemotherapy found to be more transient in comparison
For patients with platinum-sensitive recurrent ovarian cancer

Secondary Surgical Cytoreduction Not Superior in Ovarian Cancer

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Addition of surgery prior to chemotherapy does not prolong overall survival in recurrent ovarian cancer
For relapsed or refractory acute myeloid leukemia with mutations in the FMS-like tyrosine kinase 3 gene (FLT3)

Gilteritinib Superior in Relapsed, Refractory FLT3-Mutated AML

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Overall survival significantly longer, percentage of remission higher than with salvage chemotherapy
Maintaining full doses of chemotherapy

Full Chemo Doses May Improve Survival in Breast Cancer

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Maintaining full doses of chemo especially important early in the treatment course
Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients

Algorithm Based on Response, Biology Guides Neuroblastoma Tx

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Survival excellent with treatment algorithm for children with intermediate-risk neuroblastoma
For myeloma patients with progressive disease (PD) after induction therapy

Salvage Therapy Does Not Up Survival for Progressive Myeloma

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Deepening of response through salvage therapy not linked to improved progression-free, overall survival
Survivors of childhood cancer have an increased risk for all subtypes of cardiovascular disease

Risk for Cardiovascular Disease Greater for Childhood Cancer Survivors

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Exposure to ≥250 mg/m² doxorubicin-equivalent anthracycline chemo tied to risk for CVD, heart failure