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Tag: Cancer: Stomach

Pembrolizumab is noninferior to chemotherapy for overall survival among patients with programmed death ligand 1

ASCO: Pembrolizumab Noninferior to Chemo in Advanced Gastric Cancer

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For patients with PD-L1 combined positive score of ≥10, pembrolizumab prolongs overall survival
For patients with previously treated advanced gastric cancer or gastro-esophageal junction cancer

Pembrolizumab Not Better Than PTX for Advanced Gastric Cancer

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Survival no better with second-line pembrolizumab than paclitaxel for gastric, gastro-esophageal cancer
Antibiotic treatment for Helicobacter pylori in patients who underwent endoscopic resection of early-stage gastric cancer or high-grade adenoma is associated with a reduced rate of metachronous gastric cancer

H. Pylori Treatment Tied to Lower Metachronous Gastric Cancer Risk

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Those treated after early CA also had improvement in atrophy grade at gastric corpus lesser curvature
Racial and ethnic disparities in the use of preoperative chemotherapy exist among patients with gastric cancer in the United States

Disparities Seen in Gastric Cancer Patients’ Receipt of Pre-Op Chemo

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Racial, ethnic disparities in treatment also affect disparities in overall survival
Ogivri (trastuzumab-dkst) has been approved by the U.S. Food and Drug Administration as the nation's first biosimilar drug to treat certain breast and stomach cancers

FDA Approves Biosimilar Ogivri for Breast, Stomach Cancers

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Ogivri is approved to treat HER2+ breast and gastric or gastroesophageal junction adenocarcinoma cancers
Long-term proton pump inhibitor use is associated with increased risk of gastric cancer even after Helicobacter pylori eradication therapy

PPI-Gastric Cancer Link Remains After H. Pylori Eradication

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Increased risk seen in H. pylori-infected subjects who received eradication therapy
Since 1984

Gastric Cancer Incidence Down, Survival Up

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Incidence declined between 1984 and 2014, but long-term survival rates are still low
Ramucirumab appears to be safe and effective for the treatment of advanced gastric cancer

Ramucirumab Shows Promise in Care of Advanced Gastric Cancer

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In two separate trials, hazard ratios for overall survival favor treatment with ramucirumab
Rates of major upper abdominal cancer resections in octogenarians are increasing

Upper Abdominal Cancer Resections Up in Octogenarians

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Increase in resection rates driven by trends in hepatic and pancreatic resections

Reconstruction Method in Gastric CA Surgery Affects Bone Density

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Billroth-I reconstruction better than Roux-en-Y for preventing bone mineral density loss