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Tag: Cancer: Rectal

As many as one in six colorectal cancer patients under the age of 50 have genetic traits that greatly increase the risk of cancer

CRC in Patients Under 50 Often Caused by Genetic Mutations

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One in six diagnosed under 50 have at least one gene mutation that ups risk of cancer
Administration of cytotoxic T-cells targeting mutant KRAS G12D can induce tumor regression in metastatic colorectal cancer

Cytotoxic T-Cells Can Induce Metastatic CRC Regression

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Regression of tumors reported after administration of cytotoxic T-cells targeting mutant KRAS G12D
Statins seem not to be associated with the risk of colorectal adenoma

Meta-Analysis: Statins Cut Risk of Advanced Colorectal Adenoma

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In meta-analysis, statin use linked to reduced risk of advanced, but not any colorectal adenoma
Regular aspirin use is associated with a lower risk of colorectal carcinomas with low concentrations of tumor infiltrating lymphocytes

Immune Response May Be Key to Chemopreventive Effect of Aspirin

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Link seen for colorectal tumors with low levels of tumor infiltrating lymphocytes
Colorectal cancer detected after colonoscopy examination is more often located in the proximal colon and more likely to have DNA mismatch repair deficiency

CRC Detected After Colonoscopy Often Located in Proximal Colon

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Tumors more likely to have DNA mismatch repair deficiency, less likely to be metastatic
Colon capsule endoscopy (CCE)

Review: Colon Capsule Endoscopy Accurate in Polyp Detection

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Second-generation CCE has high sensitivity and specificity for polyps >6 mm and >10 mm
Fecal immunochemical testing has advantages as a colorectal cancer screening method

Advantages of FIT As CRC Screening Method Discussed

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FIT has several advantages over gFOBT, but practical concerns should be considered
Healthy living can lower the odds for colorectal cancer for men who are at high genetic risk for the disease

Men With Genetic Risk of CRC May Lower Risk Via Healthy Lifestyle

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Adopting healthy lifestyle can cut 25-year risk for the disease from 29 to 13 percent
For patients with early-stage colorectal cancer

Metabolic Syndrome and Obesity Up Risk of Mortality in CRC

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Obese patients with metabolic syndrome have increased risk of all-cause, CRC-related death
The American Academy of Family Physicians has graded the recommendation for colorectal cancer screening as a B recommendation

AAFP Downgrades USPSTF CRC Screening Recommendation

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AAFP recommends fecal immunochemical tests, flexible sigmoidoscopy, colonoscopy