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Tag: Cancer: Ovarian

BRCA testing has shifted from being primarily used in cancer patients to being used in unaffected women

BRCA Mutation Testing Shifts to Unaffected Women

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From 2004 to 2014, greater percent of testing in unaffected women versus cancer patients
Zejula (niraparib) has been approved by the U.S. Food and Drug Administration to treat adult women with recurrent epithelial ovarian

FDA Approves Zejula for Certain Female Cancers

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PARP inhibitor may help fight tumors affecting the ovaries, fallopian tubes, or peritoneum
For women with low-grade serous carcinoma of the ovary or peritoneum

Hormonal Maintenance Tx Ups PFS in Low-Grade Serous Cancer

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Significantly longer progression-free survival in low-grade serous carcinoma of the ovary or peritoneum
Coffee consumption speeds the time to bowel movement after complete staging surgery of gynecologic cancers

Coffee Speeds Time to Bowel Movement After Gynecologic Sx

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Findings for patients after complete staging surgery
Diagnostic laparoscopy reduces the number of futile laparotomies in women with suspected advanced-stage ovarian cancer

Laparoscopy Can Prevent Futile Primary Cytoreductive Surgery

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Findings in women with suspected advanced-stage ovarian cancer
The drug Rubraca (rucaparib) has been granted accelerated approval by the U.S. Food and Drug Administration to treat advanced ovarian cancer.

FDA Grants Fast-Track Approval to Ovarian Cancer Drug

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Rubraca's use is specific to women with deleterious BRCA mutations
Carcinosarcomas of the uterus and ovary have mutations in cancer genes previously identified in uterine and ovarian carcinomas and in genes encoding histones H2A and H2B

Mutations Identified in Uterine, Ovarian Carcinosarcomas

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Mutations in previously ID'd cancer genes; excess of mutations in genes encoding histone H2A, H2B
For patients with stage IIIC to IV ovarian cancer

Neoadjuvant Chemotherapy Use Up in Ovarian Cancer Treatment

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NACT use up from 2003 to 2012; linked to shorter overall survival in stage IIIC but not stage IV disease
Ovarian cancer mortality is down dramatically in many parts of the world

Oral Contraceptives May Be Cause of Drop in Ovarian CA Mortality

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Rates down 16 percent in U.S., 8 percent in Canada, and 10 percent in Europe over a decade
Guidelines have been developed for neoadjuvant chemotherapy use for newly diagnosed

Recs Developed for Neoadjuvant Chemo in Ovarian Cancer

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Guidance provided for clinicians treating women with stage IIIC or IV epithelial ovarian cancer