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Home Tags Cancer: Ovarian

Tag: Cancer: Ovarian

Deleterious mutations in RAD51C and RAD51D genes are associated with increased risk of epithelial ovarian cancer

RAD51 Mutations Confer Moderate Risk of Ovarian Cancer

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RAD51C and RAD51D deleterious mutations linked to increased risk of epithelial ovarian cancer
Multigene testing for hereditary breast and/or ovarian cancer identifies more mutations that are likely to change clinical management

Multigene Test IDs More at Risk for Hereditary Breast/Ovarian CA

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Testing for mutations other than BRCA1/2 in HBOC may change clinical management for women, families
About thirty percent of women with epithelial ovarian cancer survive for more than 10 years

~30 Percent With Epithelial Ovarian CA Survive Long Term

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Predictors for long-term survival include younger age, early stage, low grade, non-serous histology
Intraperitoneal chemotherapy significantly improves survival among women with advanced ovarian cancer; however

Intraperitoneal Chemotherapy Ups Ovarian Cancer Outcomes

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However, only 41 percent of suitable candidates actually receive the therapy
The R-enantiomer of ketorolac is enriched in peritoneal fluids and inhibits peritoneal cell GTPase activity with administration after ovarian cancer surgery

Novel Pharmacological Activity for R-Ketorolac in Ovarian Cancer

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R-enantiomer enriched in peritoneal fluids, inhibits peritoneal cell GTPase activity
Chemotherapy dose reduction is associated with worse survival in ovarian cancer

Worse Survival With Chemo Dose Reduction in Ovarian Cancer

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Lower average relative dose intensity linked to worse overall and ovarian cancer-specific survival
Undergoing chemotherapy before surgery may help women battling advanced ovarian cancer

Benefits for Surgery Before Chemo in Advanced Ovarian CA

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Appears to raise quality of life without shortening survival
Screening with a multimodal strategy

Multimodal Strategy Improves Ovarian Cancer Detection

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Screening using risk of ovarian cancer algorithm linked to increased number of screen-detected iEOCs
Women diagnosed with ovarian cancer are now much more likely to survive the disease than they were several decades ago

Survival Improving for Women With Ovarian Cancer

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Women diagnosed today 50 percent less likely to die than they were in the 1970s
Salpingectomy alone may be a risk management option for women at hereditary risk of ovarian cancer

Review Examines Salpingectomy Alone for Cutting Ovarian CA Risk

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Recent evidence suggests fallopian tube epithelium is origin of most high-grade serous cancers