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Tag: Cancer: Lung

Osimertinib is more effective than platinum-pemetrexed therapy in patients with T790M-positive advanced non-small-cell lung cancer whose disease has progressed during first-line epidermal growth factor receptor tyrosine kinase inhibitor treatment

Osimertinib Bests Platinum-Pemetrexed in T790M+ NSCLC

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Significantly longer duration of progression-free survival with osimertinib vs platinum-pemetrexed
Circulating exosomes released under intermittent hypoxia conditions

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

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IH-induced exosomes from mice significantly promote TC1 malignant properties
An updated index incorporating gene and molecular alterations can predict survival in non-small-cell lung cancer with brain metastases

Updated Index Predicts Survival in NSCLC With Brain Metastases

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Significant prognostic factors include four factors from earlier index, plus EGFR and ALK alterations
Pembrolizumab is associated with longer progression-free and overall survival for patients with non-small-cell lung cancer with programmed death ligand 1 expression on at least 50 percent of tumor cells

Pembrolizumab Ups Survival in NSCLC With PD-L1 Expression

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Findings in patients with advanced NSCLC with PD-L1 expression on at least 50 percent of tumor cells
Longitudinal changes in depression are associated with differences in mortality among patients with lung cancer

Changes in Depression Symptoms Tied to Mortality in Lung Cancer

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Increased risk with new-onset depression, persistent depression, but not depression symptom remission
Outpatients find lung cancer screening decision aids helpful

Lung Cancer Decision Aids Are Helpful for Patients

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Patient understanding of lung cancer screening increased after participation in focus groups
Stereotactic body radiation therapy seems to provide a significant survival advantage for older patients with early-stage non-small-cell lung cancer

ASTRO: SBRT Ups Survival in Older Early-Stage NSCLC Patients

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Findings suggest SBRT should be standard for patients treated with radiation for stage I NSCLC
For patients with non-small-cell lung cancer

Similar NSCLC Survival for Surgical, Endosonographic Staging

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Five-year survival not significantly different after mediastinoscopy or endosonographic staging
Whole brain radiotherapy seems to offer limited clinical benefit for patients with non-small-cell lung cancer with metastases

Whole Brain Radiotherapy Offers Little Benefit in Brain Mets

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Randomized trial shows limited clinical benefit for patients with NSCLC and brain metastases
Targeted therapies that do not contain erlotinib can be beneficial for patients with KRAS-mutated advanced non-small-cell lung cancer

Targeted Therapies Beneficial in KRAS-Mutated NSCLC

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Improved progression-free survival for patients treated with therapy not containing erlotinib