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Tag: Cancer: Leukemia

AACR: Novel COVID-19 Vaccine Aimed at Immunocompromised Patients

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CoVac-1, a peptide vaccine, induces T-cell immune responses in those with B-cell deficiencies, particularly leukemia and lymphoma patients

Ivosidenib + Azacitidine Ups Event-Free Survival in IDH1-Mutated AML

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Event-free survival significantly longer compared with placebo and azacitidine for newly diagnosed IDH1-mutated AML

AACR: Resistance Mechanisms to CAR-T Cell Therapy ID’d in ALL

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Mechanisms of resistance detectable prior to treatment and include hypermethylation of PCR2 targets in embryonic and cancer stem cells

Durable Remission Seen in Two CLL Patients After CAR T Cell Therapy

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CAR T cells detectable more than 10 years after infusion with sustained remission in both patients

Polygenic Score Helps Guide Choice of Chemo for Pediatric AML

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Polygenic score based on single nucleotide polymorphisms in the ara-C pathway genes may predict treatment outcomes

Prognostic Index May ID CLL Patients Who Will Not Need Treatment

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Novel prognostic index CLL-WONT identifies patients with chronic lymphocytic leukemia who are at low risk for ever requiring treatment

Overall, Night Shift Work Not Tied to Higher Lymphoma Risk

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However, nonlinear association seen between night shifts and chronic lymphocytic leukemia

Long-Term Outcomes Described for Survivors of Childhood ALL

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Life challenges more negatively impacted in younger, female, relapsed patients; socializing more positively impacted in older patients

Global Burden of Chronic Lymphocytic Leukemia Up From 1990 to 2019

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Incidence higher for men versus women, adults older than 70 years, and individuals living in high social-demographic index regions

Survival Increase Seen for Adults With Relapsed Ph+ ALL

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From 2000 to 2019, overall survival progressively improved for patients with Philadelphia-positive ALL who had posttransplant relapse