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Tag: Cancer: Leukemia

Many older patients with acute myeloid leukemia do not receive any active treatment

Many Older Patients With AML Not Receiving Active Treatment

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No active treatment more likely with older age, lower household income, unmarried status, comorbidities
First-degree relatives of patients with hematological malignancies have increased relative risks for the same tumor types and some different hematological malignancies

Hematological Malignancy Risk Up for First-Degree Relatives

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Increased familial relative risks for the same tumor type for most hematological malignancies
A breakthrough gene therapy will be covered for certain types of lymphoma and leukemia

Medicare to Cover CAR-T Therapy for Leukemia, Lymphoma

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Chimeric antigen receptor T-cell therapy boosts a patient's own immune cells
For Mexican children with acute lymphoblastic leukemia

Overweight, Obesity May Up Early Mortality Risk in Pediatric ALL

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But no correlation seen for overweight or obesity with early relapse in cohort of Mexican children with ALL
For patients with previously untreated chronic lymphocytic leukemia

Ibrutinib-Rituximab Beats Chemoimmunotherapy for CLL

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Progression-free, overall survival improved in the ibrutinib-rituximab group at three years
Multiple exposures to general anesthesia may be associated with neurocognitive impairment and brain imaging abnormalities in long-term survivors of childhood acute lymphoblastic leukemia

Anesthesia Tied to Neurocognitive Impairment in Childhood ALL Survivors

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Survivors experience impairment with exposure to propofol, fluranes, longer anesthesia duration
A substantial proportion of older patients with high-risk acute myeloid leukemia treated with chemotherapy are long-term survivors

High Response Seen for Chemo in Seniors With High-Risk AML

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Complete response rate for patients treated with chemo was 69 percent; three-year OS was 21 percent
For older patients with blood cancers

Gait Speed Is Prognostic in Older Patients With Blood Cancer

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Decrease in gait speed linked to higher mortality, increased odds of unplanned hospitalization, ED use
Allogeneic hematopoietic cell transplantation with an unrelated donor results in better transplantation outcomes than cord blood transplantation in acute myeloid leukemia patients with active disease

Allo-HCT With Unrelated Donor Tied to Better Outcomes in AML

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In active AML, outcomes superior for allo-HCT with unrelated donor than for cord blood transplantation
Venetoclax-obinutuzumab is associated with longer progression-free survival than chlorambucil-obinutuzumab among patients with untreated chronic lymphocytic leukemia and coexisting conditions

ASCO: Combo Regimen Effective in CLL With Coexisting Conditions

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Progression-free survival longer with venetoclax-obinutuzumab versus chlorambucil-obinutuzumab