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Tag: Cancer: Leukemia

For patients with previously untreated chronic lymphocytic leukemia

Ibrutinib-Rituximab Beats Chemoimmunotherapy for CLL

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Progression-free, overall survival improved in the ibrutinib-rituximab group at three years
Multiple exposures to general anesthesia may be associated with neurocognitive impairment and brain imaging abnormalities in long-term survivors of childhood acute lymphoblastic leukemia

Anesthesia Tied to Neurocognitive Impairment in Childhood ALL Survivors

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Survivors experience impairment with exposure to propofol, fluranes, longer anesthesia duration
A substantial proportion of older patients with high-risk acute myeloid leukemia treated with chemotherapy are long-term survivors

High Response Seen for Chemo in Seniors With High-Risk AML

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Complete response rate for patients treated with chemo was 69 percent; three-year OS was 21 percent
For older patients with blood cancers

Gait Speed Is Prognostic in Older Patients With Blood Cancer

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Decrease in gait speed linked to higher mortality, increased odds of unplanned hospitalization, ED use
Allogeneic hematopoietic cell transplantation with an unrelated donor results in better transplantation outcomes than cord blood transplantation in acute myeloid leukemia patients with active disease

Allo-HCT With Unrelated Donor Tied to Better Outcomes in AML

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In active AML, outcomes superior for allo-HCT with unrelated donor than for cord blood transplantation
Venetoclax-obinutuzumab is associated with longer progression-free survival than chlorambucil-obinutuzumab among patients with untreated chronic lymphocytic leukemia and coexisting conditions

ASCO: Combo Regimen Effective in CLL With Coexisting Conditions

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Progression-free survival longer with venetoclax-obinutuzumab versus chlorambucil-obinutuzumab
For high-risk and older patients with previously untreated chronic lymphocytic leukemia

Ibrutinib, Venetoclax Active in High-Risk, Seniors With CLL

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Findings seen in phase 2 study of combo regimen for first-line treatment of chronic lymphocytic leukemia
Octogenarians with acute myeloid leukemia have a one-month mortality rate of 41 percent and overall survival of 1.5 months

Octogenarians With Acute Myeloid Leukemia Have Poor Survival

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Overall survival 1.5 months; survival improved for those receiving chemotherapy
Venetoclax (VENCLEXTA) has been approved to treat adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma

FDA Approves Venetoclax for Chronic Lymphocytic Leukemia

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In randomized trial, drug demonstrated statistically significant improvement in progression-free survival
Venetoclax (VENCLEXTA) has been approved to treat adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma

FDA Approves Venetoclax for Chronic, Small Lymphocytic Leukemia

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In randomized trial, drug demonstrated statistically significant improvement in progression-free survival