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Tag: Cancer: Leukemia

Dasatinib is associated with improved survival for pediatric patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

Dasatinib Tops Imatinib for Ph+ Acute Lymphoblastic Leukemia

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Four-year cumulative risk of any relapse lower for dasatinib in the context of intensive chemotherapy
For patients with chronic lymphocytic leukemia in routine care

Survival Up for Chronic Lymphocytic Leukemia 1995 to 2017

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Improvement in median overall survival from 5.8 years in 1995 to 2011 to not reached in 2009 to 2017
In a study published in the December issue of JACC: CardioOncology

Risk Score Developed to Help ID Heart Failure Risk in Leukemia

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Risk score identifies risk among patients with acute leukemia treated with anthracyclines before chemo
Testosterone replacement is associated with an improvement in body composition among younger male cancer survivors with low-normal morning total serum testosterone

Testosterone Replacement May Benefit Younger Male Cancer Survivors

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Benefits include significant improvement in body composition measurements over six months
Exposure to medical radiation from computed tomography scans is associated with an increased risk for thyroid cancer and leukemia

Radiation From CT Scans Linked to Thyroid Cancer, Leukemia

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Elevated risk stronger in women than men; risk for non-Hodgkin lymphoma increased in patients ≤45
Survivors of chronic lymphocytic leukemia have an increased risk for second primary malignancy

Risk for Second Primary Malignancy Up in CLL Survivors

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SPM risk higher for men and nonwhites, after chemotherapy, for recent years of diagnosis, for advanced age
For relapsed or refractory acute myeloid leukemia with mutations in the FMS-like tyrosine kinase 3 gene (FLT3)

Gilteritinib Superior in Relapsed, Refractory FLT3-Mutated AML

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Overall survival significantly longer, percentage of remission higher than with salvage chemotherapy
For adult survivors of childhood acute lymphoblastic leukemia

Exercise Intolerance May Harm Neurocognition in ALL Survivors

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Exercise intolerance tied to impaired neurocognition in adult survivors of childhood ALL
Low bone mineral density is common in childhood leukemia and lymphoma survivors

Factors Predict Low BMD in Pediatric Blood Cancer Survivors

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Low bone mineral density detected during guideline-recommended dual-energy X-ray absorptiometry
Cardiovascular adverse drug reactions occur in association with ibrutinib

Severe Adverse Cardiovascular Events Associated With Ibrutinib

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Risk up for severe, sometimes fatal, events, including supraventricular arrhythmias, CNS events