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Tag: Cancer: Cervical

Many populations have increasing or stabilized incidence trends in cervical adenocarcinoma

Cervical Adenocarcinoma Rates Increased in Some Populations

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Increasing and stabilizing incidence trends seen for several subpopulations; declines attenuated in SCC
The number of cervical precancers in the United States declined from 2008 to 2016

CDC: Recent Decline Seen in High-Grade Cervical Lesions

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Vast majority of cervical precancer cases attributable to HPV types targeted by 9-valent HPV vaccine
For women with cervical intraepithelial neoplasia grade 2 or 3 associated with high-risk human papillomavirus

Histologic Clearance of CIN2/3 Seen With HPV Therapeutic Vaccine

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In phase II trial, rate of complete resolution of CIN2/3 significantly higher for vaccine versus placebo group
Routine vaccination of young girls aged 12 to 13 years with human papillomavirus vaccine results in a reduction in preinvasive cervical disease

Drop Seen in Preinvasive Cervical Disease With HPV Vaccination

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Vaccine effectiveness increased for immunization at younger age
The current standard of care for advanced cervical cancer -- external beam radiation therapy and chemotherapy in combination with brachytherapy -- provides significantly higher overall survival over chemoradiation alone; however

Brachytherapy Boost Ups Survival in Locally Advanced Cervical Cancer

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Findings observed regardless of treatment duration; disparities for brachytherapy use seen in vulnerable populations
The proportion of human papillomavirus 16/18-positive cervical intraepithelial neoplasia grades 2 to 3 or adenocarcinoma in situ declined from 2008 to 2014

Decline Observed in HPV Type 16/18 Cervical Precancers in U.S.

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Greatest declines seen among vaccinated women; decreases also seen in unvaccinated women
In the absence of further intervention

44.4 Million Estimated to Be Diagnosed With Cervical Cancer by 2069

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From 2020 to 2069, 6.7 to 7.7 million cases could be averted by scaling up HPV vaccination by 2020
A deep learning-based visual evaluation algorithm can detect cervical precancer/cancer with higher accuracy than conventional cytology

Algorithm Evaluates Cervical Images to ID Precancer, Cancer

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Deep learning-based algorithm was validated using archived, digitized cervical screening images
Less than two-thirds of eligible 30- to 65-year-old women are up to date with cervical cancer screening

Cervical Cancer Screening Rates ‘Unacceptably Low’

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Just 64.6 percent of 30- to 65-year-old women up to date, but Pap-HPV cotesting has increased
The presence of certain high-risk human papillomavirus types predicts future risk for high-grade cervical cancer even among women with no cellular indications of cancer at baseline

HPV Ups Cervical Cancer Risk, Even With No Cellular Signs

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HPV-16/18 confers strong future risk, particularly in women younger than 30 years